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Fixed-drug Eruptions: What can we Learn from a Case Series?
Ratinder Jhaj1, Deepa Chaudhary2, Dinesh Asati3
1Department of Pharmacology and Toxicology, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
Indian Journal of Dermatology
|August 7, 2018
Summary
Fixed-drug eruptions (FDEs) are common adverse drug reactions, frequently caused by antimicrobials and NSAIDs. A history of FDE increases the risk of multiple and extensive lesions upon re-exposure.
Area of Science:
- Dermatology
- Pharmacology
- Clinical Medicine
Background:
- Fixed-drug eruptions (FDEs) are characterized by recurrent, localized skin lesions upon re-exposure to an offending agent.
- Understanding FDE trends is crucial for managing adverse drug reactions.
Purpose of the Study:
- To analyze trends in fixed drug eruptions (FDEs).
- To identify causative drugs and patient risk factors associated with FDEs.
Main Methods:
- Retrospective analysis of FDE cases from March 2014 to May 2017.
- Inclusion in routine pharmacovigilance activities.
Main Results:
- FDEs constituted 8.4% of adverse drug reactions and 11.1% of cutaneous reactions.
- Antimicrobials (80.6%) and NSAIDs (20.8%) were the most common culprits.
- A history of FDE was associated with a higher likelihood of multiple lesions.
Conclusions:
- Antimicrobials and anti-inflammatory drugs are frequent causes of FDEs.
- Patients with a prior FDE history are prone to more severe presentations.
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