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Isolation of Early Hematopoietic Stem Cells from Murine Yolk Sac and AGM
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Mouse Yolk Sac Hematopoiesis.

Toshiyuki Yamane1

  • 1Department of Stem Cell and Developmental Biology, Mie University Graduate School of Medicine, Tsu, Japan.

Frontiers in Cell and Developmental Biology
|August 7, 2018
PubMed
Summary

The mouse yolk sac initiates hematopoiesis, producing primitive erythroid cells and other blood cells. Some yolk sac-derived cells, like macrophages and B cells, may persist into adulthood, contributing to adult hematopoietic systems.

Keywords:
B-1 B cellblood cell developmentembryonic hematopoiesisfetal hematopoiesismacrophageyolk sac

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Area of Science:

  • Developmental Biology
  • Hematology
  • Immunology

Background:

  • The yolk sac is the primary site of early hematopoiesis in embryonic development.
  • Primitive erythroid cells are the most recognized lineage originating from the yolk sac.

Purpose of the Study:

  • To review the cellular basis of mouse yolk sac hematopoiesis.
  • To discuss its contribution to embryonic and adult hematopoietic systems.

Main Methods:

  • Literature review of studies on mouse yolk sac hematopoiesis.
  • Analysis of cell lineages derived from the yolk sac.

Main Results:

  • The yolk sac produces primitive erythroid cells, multipotent hematopoietic progenitors, and other cell types.
  • Yolk sac-derived blood cells form a transient hematopoietic wave during embryonic development.
  • Certain yolk sac-derived macrophage and B cell lineages can persist into adulthood.

Conclusions:

  • The yolk sac plays a crucial role in establishing the initial hematopoietic system.
  • Persistent yolk sac-derived cells contribute to the adult hematopoietic system, highlighting early developmental origins.