Related Experiment Video
Updated: Feb 7, 2026

Author Spotlight: Advancing Therapeutics with Biocompatible Sodium Alginate Hydrogel Microspheres
Published on: June 7, 2024
[Preparation and Characterization of Pharmaceutical Properties of Tanshinone Ⅱ_A Microspheres]
Objective:
To optimize the polymer material and process condition for preparation of tanshinone Ⅱ_A microspheres by orthogonal design.
Methods:
The microspheres were prepared by emulsion solvent evaporation method. The optimum polymer material and preparation process were clarified by the comprehensive weighted score which was evaluated with the drug loading, encapsulation efficiency, and yield. The quality characterization of the tanshinone Ⅱ_A microspheres were assayed by SEM, laser particle size analyzer, TGDSC,and XRD.
Results:
The drug loading and encapsulation rate of microspheres prepared by PLLA was significantly higher than that of other polymer material. The surface of TA-PLLA-MS was round with porous structure, average particle size was( 96. 95 ± 1. 7) μm, the drug loading was( 30. 43 ± 0. 04) %,the entrapment efficiency was( 82. 72 ± 1. 51) %,and the yield was( 94. 10 ± 1. 60) %. The drug crystal form was still in the microspheres from the results of TG-DSC and XRD.
Conclusion:
The PLLA tanshinone Ⅱ_A microspheres were prepared by emulsion solvent evaporation method which was simple,stable,and enough loaded drug.
More Related Videos
05:43Preparation of Giant Vesicles Encapsulating Microspheres by Centrifugation of a Water-in-oil Emulsion
Published on: January 24, 2017
07:37TiO2-coated Hollow Glass Microspheres with Superhydrophobic and High IR-reflective Properties Synthesized by a Soft-chemistry Method
Published on: April 26, 2017
Related Concept Videos
Pharmaceutical Equivalents
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence
Physical and Chemical Properties of Matter
Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Properties of Transition Metals