Related Experiment Video
Updated: Feb 7, 2026

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface
Published on: July 10, 2014
Early-life events and developmental defects of enamel in the primary dentition
Gabriela Dos Santos Pinto1, Francine Dos Santos Costa2, Tanielley Vieira Machado3
1School of Dentistry, FASURGS, Passo Fundo, Brazil.
Insights
Low Apgar scores in newborns are linked to a higher chance of developmental defects of enamel (DDE) in primary teeth. Early-life events significantly impact children's oral health and enamel development.
Area of Science:
- Pediatric Dentistry
- Developmental Biology
- Public Health
Background:
- Developmental defects of enamel (DDE) are common in primary teeth.
- Early-life events and neonatal conditions are potential risk factors for DDE.
Purpose of the Study:
- To determine the prevalence of DDE in children aged 24-36 months.
- To investigate the association between early-life events and DDE in primary teeth.
Main Methods:
- A cohort of 503 children aged 24-36 months in Pelotas, Brazil, was studied.
- Data on maternal and child health, including Apgar scores, were collected.
- Clinical oral examinations using the DDE index (FDI) assessed enamel defects.
Main Results:
- The prevalence of DDE was 13.1% among the evaluated children.
- Children with Apgar scores below 7 had a 2.5-fold increased risk of DDE (OR=2.78).
- Hypoplasia and diffuse opacities were significantly associated with lower Apgar scores.
Conclusions:
- Early-life events, particularly low Apgar scores, are associated with an increased prevalence of DDE.
- Neonatal health status is a critical factor influencing enamel development in primary teeth.
Objective:
To investigate the occurrence of developmental defects of enamel (DDE) in the primary teeth of children aged 24-36 months and their association with early-life events.
Methods:
This study was undertaken with children aged 24-36 months in Pelotas, Southern Brazil. Information on demographic and socioeconomic characteristics, events occurring during pregnancy and neonatal events was collected previously. In this study, information on the health-related behaviours of mothers and children was collected using questionnaires and information about children's oral health was achieved through clinical oral examination. The outcome, the prevalence of DDE (≥1), was determined using the DDE index (FDI). Bivariate and multivariate logistic regression analyses were performed.
Results:
Five hundred and three mother/child dyads were evaluated, and 13.1% of the children had DDE. Multivariate analysis showed that children with Apgar scores less than 7 had around 2.5-fold higher odds of developing DDE than children with Apgar scores between 7 and 10 (OR = 2.78; 95% confidence interval [CI], 1.35-5.73). The analysis of different types of enamel defects shows that the presence of hypoplasia (OR 3.13; 95% CI, 1.35-7.27) and diffuse opacities (OR 3.95; 95% CI, 1.68-9.27) remained associated in adjusted analysis with Apgar scores.
Conclusion:
Early-life events may cause DDE. A lower Apgar score was associated with a higher prevalence of enamel defects.
Related Concept Videos
Half-life of a Reaction
Characteristics of Life
The Angiosperm Life Cycle
Introduction to Developmental Psychology
Three Developmental Domains
Physical Development
Physical processes, also known as maturation, encompass the biological changes that occur across an individual's life. These changes begin with genetic inheritance and continue through various stages, including growth in height and weight,...
Lumber Defects
Shakes are minor fractures that run along or across the wood's annual rings, while wane is...

