Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Elements and Compounds01:27

Elements and Compounds

105.0K
Pure substances consist of only one type of matter. A pure substance can be an element or a compound. An element consists of only one type of atom, while a compound consists of two or more types of atoms held together by a chemical bond.
Elements
Elements are classified as atomic or molecular based on the nature of their basic units. They are unique forms of matter with specific chemical and physical properties that cannot break down into smaller substances by ordinary chemical reactions. There...
105.0K
Periodic Classification of the Elements04:00

Periodic Classification of the Elements

59.2K
The periodic table arranges atoms based on increasing atomic number so that elements with the same chemical properties recur periodically. When their electron configurations are added to the table, a periodic recurrence of similar electron configurations in the outer shells of these elements is observed. Because they are in the outer shells of an atom, valence electrons play the most important role in chemical reactions. The outer electrons have the highest energy of the electrons in an atom...
59.2K
Classification of Elements and Compounds02:54

Classification of Elements and Compounds

73.2K
Pure substances consist of only one type of matter. A pure substance can be an element or a compound. An element consists of only one type of atom, while a compound consists of two or more types of atoms held together by a chemical bond. Elements are classified as atomic or molecular based on the nature of their basic units.
Compounds are pure substances composed of two or more elements in fixed, definite proportions. Compounds are classified as ionic or molecular (covalent) based on the bonds...
73.2K
Key Elements for Plant Nutrition02:35

Key Elements for Plant Nutrition

24.3K
Like all living organisms, plants require organic and inorganic nutrients to survive, reproduce, grow and maintain homeostasis. To identify nutrients that are essential for plant functioning, researchers have leveraged a technique called hydroponics. In hydroponic culture systems, plants are grown—without soil—in water-based solutions containing nutrients. At least 17 nutrients have been identified as essential elements required by plants. Plants acquire these elements from the...
24.3K
Replicative Cell Senescence02:15

Replicative Cell Senescence

4.4K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.4K
Elements: Chemical Symbols and Isotopes02:31

Elements: Chemical Symbols and Isotopes

126.4K
A chemical symbol is an abbreviation used to indicate an element or an atom of an element. For example, the symbol for mercury is Hg. The same symbol is used to indicate one atom of mercury (microscopic domain) or to label a container of many atoms of the element mercury (macroscopic domain).
Some symbols are derived from the common English name of the element; others are abbreviations of the name in another language — Latin, Greek or German. For example, the symbol for aluminum (common name)...
126.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Crip2 preserves hematopoietic stem and progenitor cell production through inhibition of Notch signals.

Development (Cambridge, England)·2026
Same author

Neonatal and 3-month cerebrovascular oxygenation, stability, and extraction in congenital heart disease versus control infants.

Journal of clinical and translational science·2025
Same author

Kit<sup>lo</sup> hematopoietic stem cells exhibit distinct lymphoid-primed chromatin landscapes that enhance thymic reconstitution.

Nature communications·2025
Same author

Entering a new era of tumor-infiltrating lymphocyte cell therapy innovation.

Cytotherapy·2025
Same author

Leucine zipper-based immunomagnetic purification of CAR T cells displaying multiple receptors.

Nature biomedical engineering·2024
Same author

Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma.

Nature·2024
Same journal

Circular RNA circ_0001829 attenuates G2/M arrest to promote hepatocyte proliferation by sponging miR-3095-3p following liver injury.

Cell cycle (Georgetown, Tex.)·2026
Same journal

Identification of PGF+ endothelial cells associated with plaque instability in carotid atherosclerosis by scRNA-seq and RNA-seq analysis.

Cell cycle (Georgetown, Tex.)·2026
Same journal

BMSCs-derived exosomal miR-196a-5p promotes macrophage M2 polarization and osteogenesis in postmenopausal osteoporosis through regulating Rspo2/Wnt/β-catenin signaling.

Cell cycle (Georgetown, Tex.)·2026
Same journal

MicroRNA-6833-3p drives prostate cancer progression and stemness by targeting the NUMB-mediated NOTCH signaling pathway.

Cell cycle (Georgetown, Tex.)·2026
Same journal

OTUD5 promotes AML progression by stabilizing SLC7A11 to suppress ferroptosis.

Cell cycle (Georgetown, Tex.)·2026
Same journal

MITF-Driven melanoma plasticity as a core mechanism of therapy resistance: integrating microenvironmental signaling, mechanotransduction, and metabolic reprogramming.

Cell cycle (Georgetown, Tex.)·2026
See all related articles

Related Experiment Video

Updated: Feb 7, 2026

Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

18.1K

Senescence induction universally activates transposable element expression.

Anthony R Colombo1, Harold K Elias2, Giridharan Ramsingh1

  • 1a Jane Anne Nohl Division of Hematology and Center for the Study of Blood Diseases , Keck School of Medicine of University of Southern California , Los Angeles , CA , USA.

Cell Cycle (Georgetown, Tex.)
|August 7, 2018
PubMed
Summary
This summary is machine-generated.

Senescent cells express transposable elements (TEs), which may drive inflammation and immune clearance. This study investigated TE activation across different senescence types, revealing a universal role for TEs in cellular senescence and immune response.

Keywords:
ERVISGSASPSenescencedsRNAinflammationtransposable elements

More Related Videos

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.6K
Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

47.3K

Related Experiment Videos

Last Updated: Feb 7, 2026

Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

18.1K
A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.6K
Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

47.3K

Area of Science:

  • Cellular senescence
  • Immunology
  • Genomics

Background:

  • Senescent cells secrete inflammatory factors (SASP), implicated in immune clearance.
  • Regulation of SASP and its link to transposable elements (TEs) is largely unknown.
  • Previous studies linked hypomethylating agents to TE activation and immune cell death.

Purpose of the Study:

  • To investigate the universal activation of genomic transposable elements (TEs) in senescence.
  • To explore the role of TEs in the senescence-associated secretory phenotype (SASP).
  • To understand the potential mechanisms of immune-mediated clearance of senescent cells.

Main Methods:

  • Transcriptome profiling of senescent human stem and progenitor cells (s-HSPCs).
  • Transcriptomic analysis of artificially induced senescent cell lines.
  • Analysis of TE expression and inflammatory pathways.

Main Results:

  • Senescent human stem and progenitor cells (s-HSPCs) exhibit robust expression of TEs and inflammatory pathways.
  • Artificially induced senescent cells also show significant TE activation.
  • TE activation appears to be a universal feature of cellular senescence.

Conclusions:

  • Genomic transposable elements (TEs) are universally expressed in senescent cells.
  • TE expression may contribute to the senescence-associated secretory phenotype (SASP).
  • TEs might play a crucial role in the immune-mediated clearance of senescent cells.