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Updated: Feb 7, 2026

Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound
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Transcranial Doppler in the Diagnosis of Cerebral Vasospasm: An Updated Meta-Analysis

Jean-Mathieu Mastantuono1, Christophe Combescure2,3, Nadia Elia1,3,4

  • 1Division of Anesthesiology, Department Anesthesiology, Pharmacology & Intensive Care Medicine, Geneva University Hospitals, Geneva, Switzerland.

Critical Care Medicine
|August 7, 2018
PubMed

Insights

Transcranial Doppler (TCD) and transcranial color-coded duplex Doppler (TCCD) can detect cerebral vasospasm after aneurysm rupture but cannot reliably exclude it. TCCD shows slightly better performance for the middle cerebral artery.

Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Cerebral vasospasm is a serious complication following aneurysm rupture.
  • Accurate diagnostic tools are crucial for timely intervention.
  • Transcranial Doppler (TCD) and transcranial color-coded duplex Doppler (TCCD) are non-invasive methods used to assess cerebral blood flow.

Purpose of the Study:

  • To evaluate the diagnostic performance of TCD and TCCD in detecting cerebral vasospasm.
  • To compare TCD and TCCD against angiography, the gold standard, in patients with aneurysm rupture.

Main Methods:

  • A systematic review and meta-analysis of randomized studies comparing TCD or TCCD with angiography.
  • Searched MEDLINE, Embase, and Central databases from January 2001 to October 2017.
  • Used bivariate models to pool sensitivity and specificity data.

Main Results:

  • Included 18 studies (15 on TCD, 3 on TCCD).
  • For the middle cerebral artery, pooled sensitivity was 66.7% and specificity 89.5% for TCD.
  • For the middle cerebral artery, pooled sensitivity was 81.5% and specificity 96.6% for TCCD.

Conclusions:

  • Both TCD and TCCD are likely to detect cerebral vasospasm but are not reliable for excluding it.
  • No convincing evidence suggests TCCD is superior to TCD in accuracy.
  • Limited evidence exists for TCD's usefulness in arteries other than the middle cerebral artery.
Abstract

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