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Related Experiment Video

Updated: Feb 7, 2026

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis

Published on: June 14, 2024

Toxic myopathies.

Mamatha Pasnoor¹, Richard J Barohn^1,2, Mazen M Dimachkie¹

¹Neuromuscular Division, Department of Neurology.

Current Opinion in Neurology

|August 7, 2018

Summary

This summary is machine-generated.

Recent advances in drug-induced muscle toxicity focus on statins and immune checkpoint inhibitors. Statin-associated necrotizing autoimmune myopathy (SANAM) involves HMGCR antibodies and requires immunosuppression.

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Area of Science:

Pharmacology
Toxicology
Immunology

Background:

Drug-induced muscle toxicity is a significant clinical concern.
Statins and immune checkpoint inhibitors (ICIs) are common causes of myopathy.
Understanding mechanisms and management is crucial for patient care.

Purpose of the Study:

To review recent advances in drug-induced muscle toxicity.
To highlight myopathies caused by statins and ICIs.
To provide an overview of rare steroid myopathies.

Main Methods:

Literature review of recent studies on drug-induced myopathies.
Focus on mechanisms, diagnosis, and management of statin-induced myopathy and ICI-induced myopathy.
Analysis of pathological and immunological features.

Main Results:

Statin muscle injury can be direct toxicity or autoimmune, distinguished by lab tests and pathology.
Statin-associated necrotizing autoimmune myopathy (SANAM) is linked to HMGCR autoantibodies in 66% of cases.
SANAM involves MHC-I expression on muscle fibers and requires long-term immunosuppression; ICIs present novel challenges.

Conclusions:

Distinguishing direct toxicity from autoimmune mechanisms in statin myopathy is key.
SANAM is an autoimmune myopathy associated with HMGCR antibodies, requiring intensive immunosuppressive therapy.
ICI-induced myopathies represent a growing area of concern requiring further research and management strategies.