Related Experiment Video
Updated: Feb 7, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
Time is life: EpAssistant - a new tool for the automatic identification of anti-HLA antibody epitope specificity in
Keylla S U Aita1, Semiramis J H Monte2, Adalberto S Silva3
1Distance Education Center, Federal University of Piaui, Rua Olavo Bilac - Bairro Centro, CEP: 64280001 Teresina, Piaui, Brazil; Immunogenetics and Molecular Biology Laboratory, Federal University of Piaui, Teresina, Piaui, Brazil.
Background And Objectives:
This work aims to present the expert system EpAssistant, a platform algorithm designed to accurately and automatically identify the EPLETS specificities of anti-HLA (Human Leukocyte Antigen) antibodies in the sera of transplantation candidates.
Materials And Methods:
RESULTS: As preliminary results, we present the development and establishment of the EpAssistant platform. EpAssistant analyses can be performed for Class I (-A, B and C) and Class II (-DR, -DQ and -DP) HLA molecules.
Conclusions:
EpAssistant automates the EPLETS reactivity analysis process and drastically reduces the time required to produce final results, enabling large-scale data analyses in a simple, inexpensive and rapid manner and facilitating the allocation of donated organs via the EPLETS Virtual Crossmatch (EVxM) system.
More Related Videos
10:37Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
Published on: October 20, 2021
08:09Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope
Published on: March 24, 2017
Related Concept Videos
Half-life of a Reaction
Automatic Processing and Automatic Social Behavior
Characteristics of Life
The Angiosperm Life Cycle
The Tree of Life - Bacteria, Archaea, Eukaryotes
Antibody Structure
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...