Related Experiment Video
Updated: Feb 7, 2026

Restraint to Induce Stress in Mice and Rats
Published on: December 6, 2024
Environmental enrichment prevents acute restraint stress-induced anxiety-related behavior but not changes in
Leonardo Santana Novaes1, Nilton Barreto Dos Santos1, Juliano Genaro Perfetto1
1Department of Pharmacology, Institute of Biomedical Science, University of São Paulo, São Paulo, 05508-000, Brazil.
Abstract:
Previous studies showed that acute restraint stress or transient elevation of glucocorticoid (GC) stress hormones produces emergent changes in both anxiety behavior and dendritic branches in the basolateral amygdala complex (BLA) of rats. In this work, we demonstrate that exposure to environmental enrichment (EE) prevented stress-induced increases in anxiety (emerging 10 days post-stress) in adult rats without blocking stress-induced dendritic branch remodeling in the BLA nor stress-induced enhancement of GC serum levels.
Related Concept Videos
Stress Prevention and Stress Management Techniques I
Conscientiousness
Conscientious individuals tend to be organized, responsible, and disciplined. They prioritize completing tasks and following structured routines,...
Stress Prevention and Stress Management Techniques V
Stress Prevention and Stress Management Techniques VI
Motivation and Self-Determination
Motivation, the driving force behind behavior, plays a pivotal role at every stage of the change process. The research...
Stress Prevention and Stress Management Techniques II
Type A Personality: Driven and Easily Stressed
Individuals with Type A personalities are often highly competitive and ambitious and operate with a strong sense of urgency. Commonly labeled as...
Stress Prevention and Stress Management Techniques III
The Role of Exercise in Stress Management
Regular physical activity is essential for reducing stress and promoting cardiovascular health. Exercise strengthens the heart, enhances blood flow, keeps blood vessels flexible, and helps lower blood pressure, all of which reduce the body's stress response. Research shows that adults who exercise regularly have nearly half the...
Stress Prevention and Stress Management Techniques IV

