Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sustainable Development01:43

Sustainable Development

15.2K
As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
15.2K
The Sense of Self: Reflected Self-Appraisal and Social Comparison02:57

The Sense of Self: Reflected Self-Appraisal and Social Comparison

56.1K
According to Charles Cooley, we base our image on what we think other people see (Cooley 1902). We imagine how we must appear to others, then react to this speculation. We don certain clothes, prepare our hair in a particular manner, wear makeup, use cologne, and the like—all with the notion that our presentation of ourselves is going to affect how others perceive us. We expect a certain reaction, and, if lucky, we get the one we desire and feel good about it. But more than that, Cooley...
56.1K
Oscillations In An LC Circuit01:30

Oscillations In An LC Circuit

3.1K
An idealized LC circuit of zero resistance can oscillate without any source of emf by shifting the energy stored in the circuit between the electric and magnetic fields. In such an LC circuit, if the capacitor contains a charge q before the switch is closed, then all the energy of the circuit is initially stored in the electric field of the capacitor. This energy is given by
3.1K
Forced Oscillations01:06

Forced Oscillations

8.0K
When an oscillator is forced with a periodic driving force, the motion may seem chaotic. The motions of such oscillators are known as transients. After the transients die out, the oscillator reaches a steady state, where the motion is periodic, and the displacement is determined.
8.0K
Damped Oscillations01:07

Damped Oscillations

7.3K
In the real world, oscillations seldom follow true simple harmonic motion. A system that continues its motion indefinitely without losing its amplitude is termed undamped. However, friction of some sort usually dampens the motion, so it fades away or needs more force to continue. For example, a guitar string stops oscillating a few seconds after being plucked. Similarly, one must continually push a swing to keep a child swinging on a playground.
Although friction and other non-conservative...
7.3K
Design Example: Sustainability in Concrete Building01:26

Design Example: Sustainability in Concrete Building

422
As the construction industry moves towards more eco-friendly practices, concrete's adaptability and its ability to incorporate sustainable features make it a key material in the drive towards greener building solutions.
There are multiple approaches to achieve sustainability in a commercial concrete building. For instance, construct a concrete parking area under the building, utilizing pervious concrete paver blocks in open areas to facilitate rainwater collection through an underground...
422

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electrical stimulation induces differentiation onset consistent with a therapeutic approach in neuroblastoma cells.

Scientific reports·2026
Same author

Transesophageal echocardiography and pulmonary artery catheter use and short-term outcomes in patients undergoing coronary artery bypass surgery: A multi-center retrospective study.

BMC cardiovascular disorders·2026
Same author

The high-density lipoprotein lipidome in metabolic syndrome: A systematic review.

European journal of clinical investigation·2026
Same author

Optimizing Alternating Current Electrical Stimulation Parameters to Enhance Osteoblasts Differentiation.

BioFactors (Oxford, England)·2026
Same author

Reproductive effects of combined polycystic ovary syndrome model and high-fat diet: tracing inheritance.

Reproduction (Cambridge, England)·2026
Same author

End-to-End Teleoperated Driving Video Transmission Under 6G with AI and Blockchain.

Sensors (Basel, Switzerland)·2026

Related Experiment Video

Updated: Feb 7, 2026

Femtosecond Laser Filaments for Use in Sub-Diffraction-Limited Imaging and Remote Sensing
06:16

Femtosecond Laser Filaments for Use in Sub-Diffraction-Limited Imaging and Remote Sensing

Published on: April 25, 2019

8.0K

Remote Cell Growth Sensing Using Self-Sustained Bio-Oscillations.

Pablo Pérez1,2, Gloria Huertas3,4, Alberto Olmo5,6

  • 1Instituto de Microelectrónica de Sevilla, IMSE, CNM (Universidad de Sevilla, CSIC), Av. Américo Vespucio, SN, 41092 Sevilla, Spain. pablopg@imse-cnm.csic.es.

Sensors (Basel, Switzerland)
|August 8, 2018
PubMed
Summary
This summary is machine-generated.

This article introduces a new smart sensor system designed to monitor cell cultures automatically. By turning the cell culture into a biological oscillator, the system tracks growth and cell numbers remotely through a web interface. This method simplifies laboratory tasks by reducing manual oversight and avoiding complex hardware. The researchers demonstrate a working prototype that successfully measures oscillation frequency and amplitude to provide real-time data. This technology offers a more efficient way to supervise biological assays without constant human intervention. Overall, the study shows that biological signals can be effectively harnessed for remote laboratory management.

Keywords:
OBTbioimpedancecell culturereal-time monitoringsmart sensingautomated laboratory monitoringmicrocontroller sensingbiological signal processingremote assay management

Frequently Asked Questions

More Related Videos

Integrating Remote Sensing with Species Distribution Models; Mapping Tamarisk Invasions Using the Software for Assisted Habitat Modeling SAHM
12:26

Integrating Remote Sensing with Species Distribution Models; Mapping Tamarisk Invasions Using the Software for Assisted Habitat Modeling SAHM

Published on: October 11, 2016

13.8K
Robotic Sensing and Stimuli Provision for Guided Plant Growth
08:02

Robotic Sensing and Stimuli Provision for Guided Plant Growth

Published on: July 1, 2019

8.5K

Related Experiment Videos

Last Updated: Feb 7, 2026

Femtosecond Laser Filaments for Use in Sub-Diffraction-Limited Imaging and Remote Sensing
06:16

Femtosecond Laser Filaments for Use in Sub-Diffraction-Limited Imaging and Remote Sensing

Published on: April 25, 2019

8.0K
Integrating Remote Sensing with Species Distribution Models; Mapping Tamarisk Invasions Using the Software for Assisted Habitat Modeling SAHM
12:26

Integrating Remote Sensing with Species Distribution Models; Mapping Tamarisk Invasions Using the Software for Assisted Habitat Modeling SAHM

Published on: October 11, 2016

13.8K
Robotic Sensing and Stimuli Provision for Guided Plant Growth
08:02

Robotic Sensing and Stimuli Provision for Guided Plant Growth

Published on: July 1, 2019

8.5K

Area of Science:

  • Bio-oscillation sensing within biomedical engineering
  • Cell culture monitoring systems in biotechnology

Background:

Current laboratory practices for monitoring cell cultures often require intensive manual oversight to ensure accurate data collection. This reliance on human intervention creates a significant bottleneck in high-throughput biological assays. No prior work had resolved the need for automated, remote supervision systems that minimize labor requirements. Researchers have long sought methods to integrate biological processes directly into electronic sensing frameworks. That uncertainty drove the development of systems capable of translating cellular states into measurable electronic signals. Prior research has shown that biological systems can exhibit oscillatory behavior under specific environmental conditions. This gap motivated the exploration of self-sustained oscillations as a proxy for cellular health and proliferation. The integration of these signals into web-based platforms remains a challenge for modern laboratory automation.

Purpose Of The Study:

The primary aim of this study is to introduce a smart sensor system for the real-time supervision of cell cultures. This research addresses the problem of high human labor requirements in traditional laboratory assays. The authors seek to demonstrate that cell cultures can be converted into biological oscillators for easier signal tracking. They intend to show that biological properties like growth and cell number can be observed indirectly. The motivation for this work is to simplify the acquisition and measurement of cellular data. By utilizing microcontroller features, the researchers aim to avoid the implementation of complex circuitry. The study also explores the feasibility of remote signal management through a secure web interface. Ultimately, the team seeks to provide a functional prototype that achieves reliable performance in monitoring biological samples.

The system functions by converting a cell culture into a biological oscillator. Researchers then measure the frequency and amplitude of the resulting bio-oscillation signals, which correlate directly with cell growth and total cell count.

The researchers utilize a microcontroller to extract information from the biological oscillator. This component avoids the need for complex acquisition circuitry, allowing for simpler and more efficient signal processing during the monitoring process.

A discrete prototype is necessary to bridge the gap between biological signals and digital data. This hardware allows for the remote acquisition and management of oscillation parameters through a secure web interface.

The web interface acts as the primary platform for remote data acquisition. It enables researchers to manage and observe the biological signals generated by the culture from any location with secure access.

The researchers measure the frequency and amplitude of the bio-oscillation signals. These parameters serve as the primary indicators for indirectly observing biological properties such as cell growth and total cell numbers.

The authors propose that their system significantly reduces human effort in laboratory assays. They suggest this approach allows for more efficient supervision of cell cultures compared to traditional, manual observation methods.

Main Methods:

The research team designed a smart sensor system to transform cell cultures into functional biological oscillators. They utilized a microcontroller to capture and process the resulting oscillation signals without requiring intricate hardware. The review approach involved constructing a discrete prototype to validate the sensing and remote monitoring capabilities. Investigators established a secure web interface to facilitate the transmission and management of collected data. They performed experimental measurements to evaluate the performance of the prototype under controlled conditions. The design focused on extracting frequency and amplitude parameters from the biological signals. This methodology allowed for the indirect observation of cell growth and population density. The team verified the system outcomes by comparing the measured signals against expected performance benchmarks.

Main Results:

The study demonstrates that the proposed sensor system successfully achieves real-time supervision of cell cultures. Researchers found that bio-oscillation signals provide a direct correlation to cell growth and total cell numbers. The system effectively extracts information using standard microcontroller features, eliminating the need for complex measurement circuitry. Experimental results confirm that the prototype maintains the expected performance levels during continuous operation. The frequency and amplitude of the oscillations serve as reliable indicators for monitoring the status of the biological assay. Data acquisition through the web interface proved functional for remote management of the culture environment. The authors report that this approach significantly decreases the human effort typically required for manual assay supervision. These findings validate the utility of self-sustained oscillations as a robust tool for automated laboratory monitoring.

Conclusions:

The authors propose that their smart sensor system effectively reduces the manual labor required for cell culture supervision. They demonstrate that biological oscillations provide a reliable proxy for tracking cell growth and population density. The researchers suggest that frequency and amplitude parameters offer a straightforward way to quantify cellular status. Their findings indicate that complex acquisition circuitry is unnecessary when utilizing standard microcontroller features for signal processing. The study confirms that remote management via a secure web interface is feasible for real-time assay monitoring. They conclude that the developed prototype achieves the performance benchmarks required for practical laboratory applications. The team implies that this approach could streamline workflows in various biotechnology and research settings. These results provide a foundation for future developments in automated biological signal sensing and management.