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[Cytomegalovirus Infection and Endothelial Function in Patients With Acute Myocardial Infarction]

A M Lebedeva1, E V Mariukhnich1, Z S Grievel2

  • 1Federal State Budgetary Educational Institution of Higher Education, "A. I. Evdokimov Moscow State University for Medicine and Dentistry" of the Ministry of Health of the Russian Federation.

Kardiologiia
|August 8, 2018
PubMed

Insights

Active cytomegalovirus (CMV) infection is linked to endothelial dysfunction in acute myocardial infarction (AMI) patients. CMV DNA levels were higher in AMI patients, indicating a significant association with this cardiovascular condition.

Area of Science:

  • Cardiology
  • Virology
  • Immunology

Background:

  • Endothelial dysfunction is a key factor in acute myocardial infarction (AMI).
  • Cytomegalovirus (CMV) infection is a common viral pathogen with potential cardiovascular implications.

Purpose of the Study:

  • To investigate the association between active cytomegalovirus (CMV) infection and endothelial dysfunction in patients suffering from acute myocardial infarction (AMI).

Main Methods:

  • The study involved 63 AMI patients and 42 healthy volunteers.
  • Real-time polymerase chain reaction (PCR) was used to detect CMV DNA in plasma.
  • Endothelial function was assessed using the endothelium-dependent vasodilatation (EDVD) test of the brachial artery.

Main Results:

  • Patients with AMI exhibited significantly higher concentrations of CMV DNA in their plasma compared to healthy volunteers.
  • The presence of active CMV infection was indicated by elevated CMV DNA levels.
  • Endothelial dysfunction was observed more frequently in AMI patients than in the control group.

Conclusions:

  • Active cytomegalovirus (CMV) infection is associated with endothelial dysfunction in patients with acute myocardial infarction (AMI).
  • These findings suggest CMV may play a role in the pathophysiology of AMI.
Abstract

Keywords:
acute myocardial infarctioncytomegalovirusendothelial functionherpes virus

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