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Updated: Feb 6, 2026

Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay
Published on: November 11, 2018
Functional implications of Rab27 GTPases in Cancer
Zhihong Li1, Rui Fang1, Jia Fang2
1Department of Orthopaedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Background:
The Rab27 family of small GTPases promotes the progression of breast cancer, melanoma, and other human cancers. In this review, we discuss the role of Rab27 GTPases in cancer progression and the potential applications of these targets in cancer treatment.
Main Body:
Elevated expression of Rab27 GTPases is associated with poor prognosis and cancer metastasis. Moreover, these GTPases govern a variety of oncogenic functions, including cell proliferation, cell motility, and chemosensitivity. In addition, small GTPases promote tumor growth and metastasis by enhancing exosome secretion, which alters intracellular microRNA levels, signaling molecule expression, and the tumor microenvironment.
Conclusion:
Rab27 GTPases may have applications as prognostic markers and therapeutic targets in cancer treatment.
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