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[Association of DNMT3a's single nucleotide polymorphisms with susceptibility to noise-induced hearing loss in Chinese
Haoran Guo1, Jian Cheng1, Rongjian Sheng1
1School of Public Health, Southeast University, Nanjing 210009, China.
Objective:
To investigate the potential association of DNMT3a's single nucleotide polymorphism with susceptibility to noise-induced hearing loss( NIHL) in Chinese noise-exposed workers.
Methods:
A case-control study was performed, and 998 noise-exposed workers from a chemical fibre factory and an energy company, who underwent occupational health examination in 2015, were enrolled as study subjects. Then, general information and noise exposure of the study subjects were obtained through questionnaire survey and on-site noise detection. According to the result of audiological evaluation, they were divided into case group( n = 498, high-frequency threshold shift >25 dB) and man-matched control group( n = 500, high-frequency threshold shift ≤25 dB). At last, genotyping of DNMT3a rs7590760 was conducted with TaqMan-PCR technique.
Results:
In the dominant model, the distribution of rs7590760 genotypes between the case group and the control group was statistically significant( P = 0. 001). The NIHL risk of subjects with CC/CG genotype is 1. 56 times the risk of those carrying GG genotype, with an adjusted OR = 1. 56( 95% CI 1. 22-2. 01). After the noise exposure period and noise exposure intensity were stratified, the adjusted OR values for noise exposure period ≤16 years, > 16 years and noise intensity ≤85, 86-92 and >92 dB were respectively 1. 67( 95% CI 1. 17-2. 38), 1. 52( 95% CI 1. 06-2. 17), 1. 56( 95% CI 1. 06-2. 30), 1. 67( 95% CI 0. 94-2. 99) and 1. 51( 95% CI 1. 01-2. 26).
Conclusion:
The CC/CG genotype of rs7590760 in DNMT3a gene is a potential risk factor for noise-induced hearing loss in Chinese noise-exposed workers.