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Related Experiment Video

Updated: Feb 6, 2026

TGF-β-mediated Endothelial to Mesenchymal Transition EndMT and the Functional Assessment of EndMT Effectors using CRISPR/Cas9 Gene Editing
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EndMT: A promising and controversial field.

Lei Hong1, Xiaolong Du1, Wendong Li1

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European Journal of Cell Biology
|August 8, 2018
PubMed
Summary
This summary is machine-generated.

The endothelial to mesenchymal transition (EndMT) is a cellular process implicated in development and disease. This review clarifies EndMT

Keywords:
EndMTEndothelial plasticityEndothelial-to-mesenchymal transitionFibrosis

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Area of Science:

  • Cell Biology
  • Developmental Biology
  • Pathology

Background:

  • Endothelial to mesenchymal transition (EndMT) involves endothelial cells acquiring mesenchymal cell characteristics.
  • EndMT plays roles in cardiac development and diseases like fibrosis and cancer.
  • The precise role of EndMT in specific pathologies is still under investigation.

Purpose of the Study:

  • To review diseases associated with EndMT.
  • To discuss controversies surrounding EndMT's role in disease.
  • To summarize different EndMT types, molecules, and signaling pathways.

Main Methods:

  • Literature review of EndMT-related research.
  • Analysis of studies on EndMT in development and disease.
  • Synthesis of information on EndMT mechanisms and pathways.

Main Results:

  • EndMT is a complex process with varied implications across different diseases.
  • Several molecular players and signaling cascades drive EndMT.
  • Controversies exist regarding the specific contribution of EndMT to certain disease states.

Conclusions:

  • EndMT is a significant biological process with implications for numerous diseases.
  • Further research is needed to fully elucidate EndMT's role and therapeutic potential.
  • Understanding EndMT mechanisms can inform disease treatment strategies.