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Effects of donor age, donor sex, blood-component processing, and storage on cell-derived microparticle concentrations

Egarit Noulsri1, Attakorn Palasuwan2

  • 1Research Division, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
|August 8, 2018
PubMed
Abstract

Insights

Microparticle (MP) concentrations in blood components are influenced by donor factors, processing, and storage. Fresh plasma shows significantly higher MP levels than whole blood or other components.

Area of Science:

  • Hematology
  • Transfusion Medicine
  • Biotechnology

Background:

  • Cell-derived microparticles (MPs) increase in blood components due to various factors.
  • The impact of these factors on MP concentration during blood component preparation requires further elucidation.

Purpose of the Study:

  • To investigate the influence of donor age, donor sex, blood component preparation methods, and storage conditions on microparticle concentrations.
  • To understand the dynamics of microparticle formation and concentration in blood products.

Main Methods:

  • Quantification of whole blood-derived microparticles (MPs) using flow cytometry.
  • Analysis of MP concentrations across different donor demographics and blood product types.

Main Results:

  • MP concentrations were comparable between male and female donors and did not significantly vary with donor age.
  • Fresh plasma exhibited significantly higher MP concentrations compared to unprocessed whole blood, packed red blood cells (PRBCs), and platelet concentrate (PC).
  • Stored PRBCs and fresh-frozen plasma (FFP) showed significantly higher MP counts than their fresh counterparts.

Conclusions:

  • Donor characteristics, blood component processing, and storage duration significantly affect microparticle concentrations.
  • These findings are crucial for enhancing quality control and management in routine blood product manufacturing and transfusion laboratories.
Keywords:
Blood-componentDonorFlow cytometryMicroparticleStorage

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