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LAMP1 Overexpression Predicts for Poor Prognosis in Diffuse Large B-cell Lymphoma
Qingxiu Dang1, Hong Zhou1, Juan Qian1
1Department of Hematology, Affiliated Hospital of Nantong University, Nantong, China.
Clinical Lymphoma, Myeloma & Leukemia
|August 8, 2018
Summary
Lysosomal-associated membrane protein 1 (LAMP1) is elevated in diffuse large B-cell lymphoma (DLBCL). High LAMP1 expression indicates a poorer prognosis and shorter survival for DLBCL patients.
Area of Science:
- Oncology
- Immunology
- Cell Biology
Background:
- Lysosomal-associated membrane protein 1 (LAMP1) is a protein found in lysosomes and on the plasma membrane.
- LAMP1 is implicated in tumor progression, including metastasis and cellular differentiation.
Purpose of the Study:
- To investigate LAMP1 protein expression in diffuse large B-cell lymphoma (DLBCL).
- To determine the correlation between LAMP1 expression and clinicopathologic features and prognosis in DLBCL patients.
Main Methods:
- Immunohistochemical staining was used to assess LAMP1 levels.
- 122 DLBCL tumor samples and 45 reactive hyperplasia tissues were analyzed.
- Univariate and multivariate analyses were performed to evaluate correlations.
Main Results:
- LAMP1 expression was significantly higher in DLBCL tissues compared to reactive hyperplasia.
- High LAMP1 expression correlated with a high international prognostic index and elevated lactate dehydrogenase levels.
- LAMP1 expression, lactate dehydrogenase, and international prognostic index were independent predictors of worse overall and progression-free survival.
Conclusions:
- This study provides the first evidence linking LAMP1 expression to a poor prognosis in DLBCL.
- LAMP1 may serve as a potential prognostic biomarker for DLBCL patients.
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