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Related Experiment Video

Updated: Feb 6, 2026

Bioluminescence-Based Tumor Quantification Method for Monitoring Tumor Progression and Treatment Effects in Mouse Lymphoma Models

Bioluminescence-Based Tumor Quantification Method for Monitoring Tumor Progression and Treatment Effects in Mouse Lymphoma Models

Published on: July 7, 2016

Can folate replacement induce lymphoma progression?

Nobuhiro Ariyoshi¹, Eiji Hiraoka¹, Ryosuke Koyamada²

¹Internal Medicine, Tokyo Bay Urayasu Ichikawa Medical Center, Urayasu, Japan.

BMJ Case Reports

|August 8, 2018

Summary

This summary is machine-generated.

A patient with folate deficiency and organ dysfunction improved with supplements but relapsed. Folate supplementation may have accelerated an underlying peripheral T-cell lymphoma.

Keywords:

malnutrition vitamins and supplements

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Published on: January 9, 2019

Area of Science:

Hematology
Oncology
Nutritional Science

Background:

A 43-year-old male presented with severe anemia (hemoglobin 1.3 g/dL) and multiorgan dysfunction syndrome (MODS).
Initial diagnosis was folate deficiency secondary to malnutrition.

Observation:

The patient received packed red blood cells and supplements including folate, thiamine, and vitamin B12, showing initial recovery.
A relapse occurred weeks later, characterized by pancytopenia, fever, and generalized lymphadenopathy.

Findings:

Bone marrow biopsy confirmed hemophagocytosis.
Lymph node biopsy revealed peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS).

Implications:

This case suggests that folate supplementation, while necessary for deficiency, might promote the progression of undiagnosed lymphomas.
Highlights the importance of thorough differential diagnosis in patients with severe deficiencies and rapid relapses.