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Updated: Feb 6, 2026

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
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Published on: November 7, 2025

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Family History of Breast or Prostate Cancer and Prostate Cancer Risk.

Lauren Barber1,2, Travis Gerke1,3, Sarah C Markt1

  • 1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|August 8, 2018
PubMed
Summary

A family history of breast or prostate cancer increases men's risk of developing prostate cancer, including lethal forms. This highlights the importance of familial cancer history in risk assessment.

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Area of Science:

  • Oncology
  • Epidemiology
  • Genetics

Background:

  • Prostate cancer is highly heritable, yet its association with familial breast cancer is understudied.
  • Understanding familial cancer links can improve prostate cancer risk prediction.

Observation:

  • A prospective study analyzed 37,002 U.S. men over 16 years.
  • Researchers examined associations between familial breast/prostate cancer and prostate cancer incidence (total and lethal).

Findings:

  • Familial breast cancer increased overall prostate cancer risk by 21% and lethal disease risk by 34%.
  • Family history of prostate cancer alone raised total disease risk by 68% and lethal disease risk by 72%.
  • Men with a history of both cancers also showed elevated prostate cancer risks.

Implications:

  • Family history of breast or prostate cancer is a significant risk factor for prostate cancer.
  • These findings are crucial for refining prostate cancer risk prediction models.
  • Incorporating familial cancer history can enhance early detection and prevention strategies.