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Updated: Feb 6, 2026

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas
Published on: September 5, 2011
Comparison of neurodevelopmental outcomes between monochorionic and dichorionic twins with birth weight ≤ 1500 g in
Kenji Ichinomiya1, Kenichi Maruyama2, Aya Koizumi2
1Department of Neonatology, Gunma Children's Medical Center, Gunma, Japan. ken-k-7@gcmc.pref.gunma.jp.
Objective:
To examine the relationship between chorionicity and neurodevelopmental outcomes in very low birth weight twins at 3 years of age.
Study Design:
A retrospective cohort study of 3538 twins who were admitted to 91 tertiary perinatal centers in the Neonatal Research Network of Japan between 2003 and 2012.
Results:
In a comparison of the followed-up 796 monochorionic twins and 786 dichorionic twins, the overall rate of neurodevelopmental impairment was higher in monochorionic twins; specifically, the rate of disability in the language-social area of the Japanese standardized developmental test was higher in monochorionic twins than in dichorionic twins (adjusted odds ratio, 1.55; 95% confidence interval, 1.07-2.25; P = 0.02).
Conclusions:
Chorionicity was associated with neurodevelopmental outcome (especially for language and social development) in a large cohort of very low birth weight twins who had a high rate of perinatal morbidity and neurodevelopmental impairment.
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