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Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients
09:16

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Predictors of long-term outcome in patients with biopsy proven inflammatory cardiomyopathy

Ohlow Marc-Alexander1, Michel Christoph1, Ting-Hui Chen1

  • 1Department of Cardiology, Zentralklinik, Bad Berka, Germany.

Journal of Geriatric Cardiology : JGC
|August 8, 2018
PubMed

Insights

Older age, short heart failure duration, and symptoms indicate poor prognosis in inflammatory cardiomyopathy (iCM) patients. Younger patients with longer disease duration show excellent outcomes.

Area of Science:

  • Cardiology
  • Immunology
  • Virology

Background:

  • Inflammatory cardiomyopathy (iCM) is a serious condition affecting heart function.
  • Identifying prognostic indicators is crucial for managing iCM patients.

Purpose of the Study:

  • To identify prognostic indicators in patients diagnosed with iCM via endomyocardial biopsy (EMB).

Main Methods:

  • Retrospective analysis of 503 iCM patients diagnosed between 2007-2011.
  • Combined primary endpoint included cardiac death, aborted sudden cardiac death, ICD shock, LVAD, and heart transplantation.
  • Multivariate analysis identified independent predictors of the primary endpoint.

Main Results:

  • Viral genomes detected in 79% of patients; inflammation in 44%.
  • Independent predictors for the primary endpoint: age ≥ 50 years, presence of symptomatic heart failure, and duration ≤ 28 days.
  • Patients < 50 years with > 28 days disease duration and no heart failure symptoms had 100% survival.

Conclusions:

  • Symptoms of heart failure, short disease duration, and older age predict poor outcomes in iCM.
  • Risk stratification can identify patients with excellent prognosis.
Abstract

Keywords:
Endomyocardial biopsyInflammatory cardiomyopathyOutcome

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