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Updated: Feb 6, 2026
Synthesis of Bimetallic Pt/Sn-based Nanoparticles in Ionic Liquids
Published on: August 23, 2018
In Vivo Biocompatibility of an Ionic Liquid-protected Silver Nanoparticle Solution as Root Canal Irrigant
Mohammadreza Nabavizadeh1, Yasamin Ghahramani2, Abbas Abbaszadegan2
1Oral and Dental Disease Research Center, Dental School, Shiraz University of Medical Sciences, Shiraz, Iran.
Introduction:
The aim of this study was to assess the biocompatibility of positively charged imidazolium-based ionic liquid-protected nanosilver solution (AgNPs) root canal irrigant.
Methods And Materials:
Eighteen male 4- to 5-month old Sprague-Dawley rats, weighing 200-300 gr were selected and randomly divided into 5 groups: Normal saline 0.9% (group 1), 5.25% NaOCl (group 2), 2.5% NaOCl (group 3), 2.0% chlorhexidine solution (group 4) and AgNPs at 5.7×10-8 M/L (group 5) were randomly injected in 5 sites of dorsal skin of each rat. Tissue inflammatory reaction were evaluated histopathologically after 2 h, 48 h and 14 days. Statistical analysis was done with SPSS version 21 and the Kruskal-Wallis H and Dunn tests were used to find statistically significant differences. The level of significance was set at 0.05.
Result:
All solutions irritated the highest tissue response after 48 h. Group 1 showed lower inflammatory response compared to groups 2 and 4 (P<0.05). Group 2 displayed higher inflammatory response in comparison with group 5 (P<0.05). Tissue reaction to group 5 was not more severe than the reaction to group 3 or 4. It also would irritate less inflammatory response compared to group 2 (P<0.05).
Conclusion:
Comparing with NaOCl and CHX, it is possible to label AgNPs as a tissue compatible agent.
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