Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypothyroidism conversion to hyperthyroidism: it's never too late.

Ehtasham Ahmad1, Kashif Hafeez2, Muhammad Fahad Arshad3

  • 1Endocrinology and Diabetes, Queen Elizabeth the Queen Mother Hospital, Margate, UK.

Endocrinology, Diabetes & Metabolism Case Reports
|August 8, 2018
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transseptal interventions and the interatrial septum.

Heart rhythm·2026
Same author

The treatment of acute symptomatic hyponatraemia in the hospital setting.

Best practice & research. Clinical endocrinology & metabolism·2025
Same author

Diagnostic performance of morning serum cortisol for glucocorticoid weaning in children and adults.

European journal of endocrinology·2025
Same author

Early Detection of Subclinical Myocardial Dysfunction in Familial Dilated Cardiomyopathy Using Myocardial Work Analysis.

Diagnostics (Basel, Switzerland)·2025
Same author

Incorporating a Physical Activity mHealth Tool Into a Multidisciplinary Clinical Weight Management Service in England: Service Evaluation of Steps4Health.

Journal of physical activity & health·2025
Same author

Urinary Calcium Measurement in Patients With Hypercalcaemia; Endocrine Physicians and Surgeons Survey Results From UK.

Clinical endocrinology·2025
Same journal

Combination therapy of pasireotide and pegvisomant for aggressive acromegaly with an immature PIT1-lineage PitNET.

Endocrinology, diabetes & metabolism case reports·2026
Same journal

Multivessel spontaneous coronary artery dissection in a young woman using cabergoline.

Endocrinology, diabetes & metabolism case reports·2026
Same journal

Differential reversibility of anterior and posterior pituitary dysfunction in delayed recurrent pediatric Rathke's cleft cyst.

Endocrinology, diabetes & metabolism case reports·2026
Same journal

Longitudinal evaluation of recurrent thyrotoxicosis in a single patient across four pregnancies: a case report and literature review.

Endocrinology, diabetes & metabolism case reports·2026
Same journal

Experiences with the use of asfotase alfa in three patients with childhood-onset hypophosphatasia.

Endocrinology, diabetes & metabolism case reports·2026
Same journal

Reactivation after total thyroidectomy? A thyroid eye disease case that challenges established clinical paradigms.

Endocrinology, diabetes & metabolism case reports·2026
See all related articles

Primary hypothyroidism can rarely transform into Graves

Area of Science:

  • Endocrinology
  • Autoimmune diseases
  • Thyroid disorders

Background:

  • Primary hypothyroidism, often due to Hashimoto's disease, typically requires lifelong treatment.
  • Graves' disease is the most common cause of hyperthyroidism.
  • Conversion from Hashimoto's disease to Graves' disease is rare but increasingly recognized.

Purpose of the Study:

  • To report a rare case of a patient with hypothyroidism who developed hyperthyroidism.
  • To highlight the possibility of transformation from hypothyroidism to hyperthyroidism, even after decades.
  • To emphasize the need for careful diagnosis in such cases.

Main Methods:

  • Case report of a 61-year-old female diagnosed with hypothyroidism 30 years prior.
  • Clinical and biochemical assessment of thyroid function over time.

Related Experiment Videos

  • Monitoring response to levothyroxine dose adjustments and subsequent anti-thyroid treatment.

    • Main Results:

    • The patient developed hyperthyroidism 27 years after initial hypothyroidism diagnosis.
    • Initial management involved levothyroxine dose reduction and cessation, but hyperthyroidism persisted.
    • Anti-thyroid treatment with Carbimazole was ultimately required.

    Conclusions:

    • Graves' disease can occur years after primary hypothyroidism, suggesting it may be underdiagnosed.
    • Diagnosis requires careful clinical and biochemical evaluation to distinguish from levothyroxine over-replacement.
    • Measuring anti-thyroid peroxidase (TPO) antibodies and TSH receptor antibodies (TRAB) is recommended in suspected cases.