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Alprazolam-induced dose-dependent anorgasmia: case analysis.

Kenneth R Kaufman¹, Melissa Coluccio², Michelle Linke²

¹Department of Psychiatry, Department of Neurology, and Department of Anesthesiology, Rutgers Robert Wood Johnson Medical School, USA.

|August 8, 2018

Summary

Alprazolam, a common psychiatric medication, can cause dose-dependent anorgasmia, a form of sexual dysfunction. Patients and clinicians should monitor for this adverse effect, especially with higher doses of alprazolam.

Keywords:

Alprazolam adverse effect anorgasmia anxiety disorder, major depressive disorder benzodiazepine clinical care education nonadherence obsessive–compulsive disorder, attention-deficit hyperactivity disorder sexual dysfunction

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Area of Science:

Psychiatry
Pharmacology
Sexual Medicine

Background:

Sexual dysfunction is a common side effect of psychiatric medications, impacting quality of life and treatment adherence.
Patients often do not report sexual dysfunction, and clinicians may not inquire about it.
Limited data exists on benzodiazepines, including alprazolam, and their potential to cause sexual dysfunction.

Purpose of the Study:

To report a case of dose-dependent anorgasmia associated with alprazolam use.

Main Methods:

Case analysis of a psychiatric patient.
Literature review using PubMed.

Main Results:

A 30-year-old male patient developed anorgasmia after his alprazolam dose was increased to 2.5 mg daily.
The anorgasmia was directly related to the alprazolam dose, resolving when the dose was reduced.
The patient had multiple psychiatric diagnoses and was on several other psychotropic medications, but only alprazolam dosage had changed recently.

Conclusions:

Alprazolam can induce dose-dependent anorgasmia, a significant sexual dysfunction.
Awareness of this potential adverse effect is crucial for clinicians and patients.
Regular sexual history taking is recommended in psychiatric practice.