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Pilot Study on Epigenetic Response to A Mind-Body Treatment.
M Cozzolino1, F Guarino2, S Castiglione2
1Department of Human, Philosophical and Educational Sciences, University of Salerno, Italy.
Translational Medicine @ Unisa
|August 8, 2018
Summary
Mind-body therapies alter DNA methylation patterns. Epigenetic profiles shifted from heterogeneous to homogeneous after treatment, indicating a bio-molecular impact of these interventions.
Area of Science:
- Epigenetics
- Genomics
- Mind-Body Medicine
Background:
- Epigenetics and functional genomics are increasingly used to study mind-body therapies.
- DNA microarray technology has linked stress response pathways to disease and mind-body interventions.
Purpose of the Study:
- To investigate the bio-molecular effects of a mind-body therapeutic protocol (MBT-T) on DNA methylation.
- To analyze changes in epigenetic profiles before, during, and after MBT-T.
Main Methods:
- Analysis of DNA samples from 20 individuals using the MSAP epigenetic marker.
- Biostatistical analysis including Bayesian statistics (Structure) and DNA methylation level estimation (MSAP tool).
- Comparison of epigenetic profiles at three time points: pre-treatment, 1 hour post-treatment, and 24 hours post-treatment.
Main Results:
- Bayesian analysis revealed changes in subject clustering and membership across the time points.
- Epigenetic profiles were heterogeneous before treatment and became more homogeneous after MBT-T.
- The DNA epigenetic status of subjects was demonstrably affected by the mind-body treatment.
Conclusions:
- Mind-body therapeutic protocols can induce significant changes in DNA methylation patterns.
- The study provides bio-molecular evidence for the impact of mind-body therapies on epigenetic regulation.
- Epigenetic modifications following MBT-T suggest a convergence towards a more uniform DNA methylation status.
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