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Related Concept Videos

Common Ion Effect03:24

Common Ion Effect

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Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Châtelier’s principle. Consider the dissolution of silver iodide:
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Relative Motion Analysis - Acceleration01:10

Relative Motion Analysis - Acceleration

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A slider-crank mechanism converts rotational motion from the crank into linear motion of the slider or vice versa. This mechanism consists of three main parts: the crank, the connecting rod, and the slider. The movement of the slider-crank is an example of general plane motion as the fluctuating angle between the crank and the connecting rod. Consider a segment AB where point A is at the end of the slider and point B is on the diametrically opposite end to point A, on a crack. The variance in...
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Relative Motion Analysis using Rotating Axes - Acceleration01:22

Relative Motion Analysis using Rotating Axes - Acceleration

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Consider a component AB undergoing a linear motion. Along with a linear motion, point B also rotates around point A. To comprehend this complex movement, position vectors for both points A and B are established using a stationary reference frame. The absolute velocity of point B is determined by adding the absolute velocity of point A, the relative velocity of point B in the rotating frame, and the effects caused by the angular velocity within the rotating frame.
Time differentiation is...
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Accelerators01:17

Accelerators

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Accelerators in concrete serve as admixtures to speed up the hardening process, enabling the concrete to achieve early strength faster. Although accelerators do not necessarily impact the time it takes concrete to set, they reduce this time in practice. A common accelerator is calcium chloride, which is particularly useful for hastening early strength development in cold weather or for rapid repair jobs that require quick heat generation after mixing.
The effectiveness of calcium chloride can...
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Differentiation of Common Myeloid Progenitor Cells01:15

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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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Average Acceleration01:30

Average Acceleration

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The importance of understanding acceleration spans our day-to-day experiences, as well as the vast reaches of outer space and the tiny world of subatomic physics. In everyday conversation, to accelerate means to speed up. For instance, we are familiar with the acceleration of our car; the harder we apply our foot to the gas pedal, the faster we accelerate. The greater the acceleration, the greater the change in velocity over a given time. Acceleration is widely seen in experimental physics. In...
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Assessment of Stress Effects on Cognitive Flexibility using an Operant Strategy Shifting Paradigm
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Accelerating a paradigm shift: The Common Fund Single Cell Analysis Program.

Ananda L Roy1,2, Richard Conroy1,2, Jessica Smith1,2

  • 1Office of Strategic Coordination, National Institutes of Health (NIH), 6001 Executive Boulevard, Bethesda, MD 20892, USA.

Science Advances
|August 8, 2018
PubMed
Summary
This summary is machine-generated.

Understanding the molecular profiles of human cells is crucial for health and disease. The NIH Single Cell Analysis Program (SCAP) has driven technological advances for single-cell analysis, impacting research in health and disease.

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Area of Science:

  • Biomedical research
  • Genomics
  • Cell biology

Background:

  • Understanding the molecular profiles of trillions of human cells is vital for health, disease, and treatment outcomes.
  • The National Institutes of Health (NIH) Common Fund's Single Cell Analysis Program (SCAP) was established to address this need.

Purpose of the Study:

  • To review the goals of the SCAP.
  • To provide a perspective on the program's impact on exploring human tissue heterogeneity at the cellular level.

Main Methods:

  • Technological advancements in single-cell RNA sequencing.
  • Development of multiplexed imaging techniques.
  • Integration of computational methods for data analysis.

Main Results:

  • The SCAP has catalyzed exploration of human tissue heterogeneity.
  • Significant technological progress has been made in single-cell analysis methods.

Conclusions:

  • Technological advances spurred by the SCAP will broadly impact single-cell analyses in health and disease research.
  • The program's contributions are expected to enhance our understanding of cellular functions in various biological contexts.