Related Experiment Video
Updated: Feb 6, 2026

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat
Published on: May 19, 2020
Advances in Mitral Valve Surgery
Sabine Meier1, Joerg Seeburger1, Michael A Borger2
1Department of Cardiac Surgery, Leipzig Heart Center, University of Leipzig, Struempellstrasse 39, 04289, Leipzig, Germany.
Abstract:
Mitral valve (MV) insufficiency, classified as primary and secondary mitral regurgitation (MR), is a common cause of morbidity and mortality. In industrialized countries, degenerative forms are the predominant cause of MR; however, an increasing number of patients present with secondary MR (Iung et al. EHJ 24:1231-1243, 2003). During the last decades, MV surgery experienced substantial advancements. Alain Carpentier pioneered the field of reconstructive valve surgery in the beginning of the 1970s and, since then, a plethora of innovations have led to today's landscape of MV surgery. Modern MV repair techniques including minimally invasive approaches represent the gold standard for primary MR with reconstruction rates of > 97% in high-volume reference centers (Castillo et al. JTCS 144(2):308-312, 2012). Although there is a clear strategy for treatment of primary MR with established high-quality results, the optimal course for treatment of secondary MR remains controversial. Results for a variety of MV repair techniques for secondary MR have been uniformly disappointing and there has been a recent resurgence in interest for MV replacement surgery. Innovations in equipment and imaging have led to the development of new techniques for patients with MV disease. High-risk patients who are poor candidates for surgery have been the focus for most of these techniques, usually within the construct of a multidisciplinary heart team. Efforts have been predominantly focused on less invasive strategies, usually transcatheter technologies, in these high-risk patients. This article aims to give an overview about current surgical treatment options for primary and for secondary MR with special focus on new surgical and transcatheter developments.
Insights
Mitral regurgitation (MR) treatment varies by type. Primary MR has successful surgical repair, but secondary MR treatment remains challenging, driving innovation in surgical and transcatheter approaches.
Area of Science:
- Cardiovascular Surgery
- Interventional Cardiology
Background:
- Mitral regurgitation (MR), encompassing primary and secondary types, significantly contributes to patient morbidity and mortality.
- Degenerative MR is prevalent in industrialized nations, with a growing incidence of secondary MR.
- Significant advancements in mitral valve (MV) surgery, particularly reconstructive techniques, have been made since the 1970s.
Purpose of the Study:
- To provide an overview of current surgical treatment options for primary and secondary MR.
- To highlight novel surgical and transcatheter developments for MR management.
- To address the ongoing controversy and evolving strategies for secondary MR treatment.
Main Methods:
- Review of current surgical techniques for primary and secondary MR.
- Analysis of advancements in minimally invasive approaches and transcatheter technologies.
- Discussion of treatment strategies for high-risk patients managed by multidisciplinary heart teams.
Main Results:
- Modern MV repair techniques, including minimally invasive options, achieve >97% reconstruction rates for primary MR in high-volume centers.
- Established high-quality results exist for primary MR treatment, unlike secondary MR where repair outcomes are often disappointing.
- There is a renewed interest in MV replacement surgery for secondary MR, alongside the development of new techniques, particularly transcatheter approaches for high-risk patients.
Conclusions:
- Primary MR has a clear treatment strategy with excellent surgical outcomes.
- Optimal treatment for secondary MR remains controversial, necessitating further research and innovation.
- New surgical and transcatheter technologies offer promising, less invasive options, especially for high-risk patients with MR.
Related Concept Videos
Mitral Valve Prolapse I: Introduction
Mitral Valve Prolapse II: Assessment and Management
Mitral Valve Prolapse III: Nursing Management
Heart Valves
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
Mitral Stenosis I: Introduction
Mitral Regurgitation I: Introduction

