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[Hepatopulmonary interactions].

V Fuhrmann1,2, P Tariparast3

  • 1Klinik für Intensivmedizin, Universitätsklinikum Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Deutschland. v.fuhrmann@gmx.at.

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Summary
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Clinically significant liver-lung interactions are frequent but often overlooked. This review covers pulmonary and hepatic disease interactions and their therapeutic implications.

Keywords:
Hepatopulmonary syndromeLiver cirrhosisLiver failurePneumoniaRespiratory failure

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Area of Science:

  • Medicine
  • Pulmonology
  • Hepatology

Background:

  • Liver-lung interactions are common in clinical practice but often neglected.
  • Respiratory failure affects a significant portion of patients with acute-on-chronic liver failure (ACLF).
  • Critically ill patients with cardiopulmonary diseases or sepsis can develop secondary liver failure.

Purpose of the Study:

  • To provide an overview of clinically relevant liver-lung interactions.
  • To discuss consecutively acquired pulmonary and hepatic diseases.
  • To explore therapeutic implications of these interactions.

Main Methods:

  • Literature review of clinically relevant liver-lung interactions.
  • Analysis of data on the prevalence of respiratory failure in ACLF.
  • Examination of secondary liver failure incidence in critically ill patients.

Main Results:

  • Respiratory failure is prevalent in ACLF, especially in advanced stages.
  • Secondary liver failure occurs in up to 20% of critically ill patients due to cardiopulmonary issues or sepsis.
  • The article highlights the bidirectional nature of liver-lung disease.

Conclusions:

  • Liver-lung interactions are critical and require greater clinical attention.
  • Understanding these interactions is key to managing complex patient cases.
  • This review offers insights into managing patients with combined liver and lung conditions.