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Where are modern flow techniques heading to?

Burkhard Horstkotte1, Manuel Miró2,3, Petr Solich2

  • 1Department of Analytical Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University, Akademika Heyrovského 1203, 500 05, Hradec Králové, Czech Republic. Horstkob@faf.cuni.cz.

Analytical and Bioanalytical Chemistry
|August 8, 2018
PubMed
Summary
This summary is machine-generated.

This review explores the evolution of laboratory automation, highlighting modern flow methodologies and techniques like Lab-On-Valve and Lab-In-Syringe for analytical chemistry. It compares these to traditional methods and discusses future trends.

Keywords:
Automation and miniaturizationFlow techniquesHyphenationLab-On-Valve and Lab-In-SyringeMonitoring and surveillanceSample pretreatment

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Area of Science:

  • Analytical Chemistry
  • Laboratory Automation
  • Chemical Engineering

Background:

  • Early laboratory automation relied on analytical flow approaches.
  • Modern analytical chemistry benefits from advanced flow methodologies.
  • Newer techniques offer enhanced capabilities for chemical analysis.

Purpose of the Study:

  • To provide an overview of the transition in laboratory automation from early flow approaches to current methodologies.
  • To detail recent developments and future trends in flow techniques.
  • To serve as a reference for both experienced practitioners and newcomers in the field of flow chemistry.

Main Methods:

  • Review of literature on flow methodologies and laboratory automation.
  • Focus on recently developed techniques: Lab-On-Valve and Lab-In-Syringe.
  • Comparative analysis of different flow generations and alternative automation systems (autosamplers, robotics).

Main Results:

  • Flow techniques offer advantages in sample pretreatment, in-situ/on-site monitoring, miniaturization, kinetic assays, and online coupling with analytical instruments.
  • Lab-On-Valve and Lab-In-Syringe are highlighted as complementary recent developments.
  • Critical comparison with autosamplers and robotic systems is provided.

Conclusions:

  • Flow methodologies represent a significant advancement in laboratory automation for analytical chemistry.
  • Emerging techniques and future developments, including 3D prototyping, promise further improvements.
  • Flow techniques offer unique benefits over traditional automation approaches for various analytical applications.