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Apolipoprotein E gene polymorphisms and intraventricular haemorrhage in infants born preterm: a large prospective

Mark Dzietko1, Soeren Schulz2, Michael Preuss2

  • 1Department of Pediatrics I, University Duisburg-Essen, Essen, Germany.

Developmental Medicine and Child Neurology
|August 8, 2018
PubMed

Insights

Apolipoprotein E (APOE) genotypes APOE2 and APOE4 are linked to increased risk of intraventricular hemorrhage (IVH) in preterm infants. Understanding these genetic factors is crucial for identifying susceptible infants and improving outcomes.

Area of Science:

  • Neonatal neurology
  • Medical genetics
  • Perinatal medicine

Background:

  • Preterm infants face a high risk of intraventricular hemorrhage (IVH).
  • Genetic susceptibility to IVH in this population is not well understood.
  • Apolipoprotein E (APOE) genotypes are known risk factors for cerebral hemorrhages in adults.

Purpose of the Study:

  • To investigate the association between APOE genotypes and the prevalence of IVH in preterm infants.
  • To determine if specific APOE genotypes increase the risk of severe IVH (grade III and IV).

Main Methods:

  • A prospective study comparing 5075 preterm infants with APOE3 genotype to 965 with APOE2 and 1912 with APOE4.
  • Logistic regression analysis was used, controlling for factors like gestational age, antenatal steroids, and Apgar scores.
  • The study analyzed the association between APOE genotype and grade III/IV IVH.

Main Results:

  • APOE2 and APOE4 genotypes were significantly more prevalent in infants with IVH compared to APOE3.
  • APOE2 showed an odds ratio (OR) of 1.33 (95% CI 1.00-1.76) and APOE4 showed an OR of 1.39 (95% CI 1.12-1.74).
  • Infants with two APOE polymorphisms had the highest IVH risk (OR 1.63, 95% CI 1.09-2.45).

Conclusions:

  • APOE2 and APOE4 genotypes are significant risk factors for IVH in preterm infants.
  • These findings enhance the understanding of genetic contributions to IVH development.
  • Identifying genetic predispositions can aid in targeted prevention and management strategies.
Abstract

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