[Progressive sequelae of cranio-cerebral injuries]

Progressively increasing pathological phenomena, those of a vegetovascular character in the main, develop often in the late period after closed craniocerebral trauma even if it was of a mild degree. Impaired immune response, mosaicly manifested disorders of regional volumetric cerebral blood flow and local reactivity of the cerebral vessels, and other changes are always revealed in such patients. Experimental studies showed disorders of the mechanisms of self-regulation of brain cells to be the underlying factors of these posttraumatic changes. They are reflected in particular by stable changes of fermentative reactions determining the synthesis and catabolism of cyclic nucleotides.