Related Experiment Video
Updated: Feb 6, 2026
07:49
Large-Animal Model of Donation after Circulatory Death and Normothermic Regional Perfusion for Cardiac Assessment
Published on: May 10, 2022
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Lung donation after circulatory determined death: a single-centre experience
Cristina Barbero1, Simon Messer2, Ayyaz Ali2
1Department of Cardiovascular and Thoracic Surgery, Città della Salute e della Scienza, University of Turin, Turin, Italy.
Summary
Donation after circulatory determined death (DCD) lung transplants show comparable outcomes to donation after brain death (DBD) transplants. This suggests DCD offers a viable option to increase lung donor availability and improve transplant rates.
Area of Science:
- Cardiovascular & Respiratory System
- Transplantation & Regenerative Medicine
Background:
- Donor organ shortage limits lung transplantation (LTx) opportunities.
- Donation after circulatory determined death (DCD) offers a potential solution but raises concerns about organ quality and ischemia-reperfusion injury.
- Comparing DCD LTx outcomes to standard donation after brain death (DBD) is crucial.
Purpose of the Study:
- To retrospectively analyze a single-center experience with DCD lung transplantation.
- To compare early and mid-term outcomes of DCD LTx with those from DBD donors.
Main Methods:
- A 6-year retrospective analysis of 186 lung transplants.
- Comparison of outcomes between 23 recipients of DCD donor lungs and recipients of DBD donor lungs.
Main Results:
- No significant differences in mechanical ventilation duration, ECMO support, ICU/hospital stay, or anastomotic complications were observed.
- Incidence and grade of rejection and freedom from bronchiolitis obliterans syndrome were similar between groups.
- Actuarial survival at 1 and 5 years showed a non-significant trend favoring DBD (82%/61% vs. 75%/51%).
Conclusions:
- Short- and medium-term outcomes of DCD LTx are comparable to DBD LTx.
- DCD lungs may be suitable for older recipients, with a trend towards older age in the DCD group.
- DCD LTx is a valuable clinical option for expanding the lung donor pool with favorable results.
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