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Updated: Feb 6, 2026

Large Area Substrate-Based Nanofabrication of Controllable and Customizable Gold Nanoparticles Via Capped Dewetting
Published on: February 26, 2019
Indole Derivative-Capped Gold Nanoparticles as an Effective Bactericide in Vivo
Xiaohui Zhao1,2, Yuexiao Jia2,3, Juanjuan Li2
1Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation, College of Resources and Environmental Sciences , China Agricultural University , Beijing 100193 , China.
Abstract:
We synthesize indole derivative-capped gold nanoparticles (Au_IDs) via a straightforward route to fight multidrug-resistant (MDR) bacteria. When gold nanoparticles are modified with two indole derivatives, tryptophan and 5-aminoindole, they exhibit excellent antibacterial activities against both laboratory antibiotic-sensitive and MDR bacteria. Au_IDs possess remarkable bactericidal activities against MDR bacteria killing 99.9% of MDR Escherichia coli and polymyxin-resistant Klebsiella pneumoniae after 0.5 h of incubation, which are superior to clinical antibiotics including polymyxin B and cefotaxime. By evaluating the potential of Au_IDs in wound cure, Au_IDs show outstanding capability in MDR bacterial wound infection. Our findings provide new candidates for the development of bactericides and the fabrication of wound dressings for treating MDR infection.
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