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Cytokines in aortic dissection

Tao Zeng1, Lei Shi1, Qingwei Ji2

  • 1Department of Cardiology, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|August 8, 2018
PubMed

Insights

Aortic dissection (AD) involves aortic wall inflammation and cell death. This review examines the critical role of various cytokines in AD pathogenesis and potential therapeutic strategies.

Area of Science:

  • Vascular Biology
  • Immunology
  • Pathophysiology

Background:

  • Aortic dissection (AD) is a life-threatening vascular condition.
  • Pathological mechanisms include inflammatory cell infiltration and smooth muscle cell apoptosis.
  • Cytokines are implicated in the development of AD.

Purpose of the Study:

  • To review the role of cytokines in aortic dissection.
  • To deepen the understanding of AD pathogenesis.
  • To explore potential cytokine-targeted therapies for AD.

Main Methods:

  • Literature review of studies on cytokines and AD.
  • Analysis of cytokine involvement in AD pathology.
  • Synthesis of current knowledge on cytokine-AD relationships.

Main Results:

  • Multiple cytokines, including interleukins and tumor necrosis factor, are critical in AD.
  • Cytokine signaling pathways contribute to aortic wall damage and cell death.
  • Evidence suggests a strong link between specific cytokines and AD progression.

Conclusions:

  • Cytokines play a pivotal role in the development and progression of aortic dissection.
  • Targeting cytokine pathways presents a promising avenue for future AD treatments.
  • Further research into cytokine-AD interactions is essential for advancing therapeutic strategies.

Keywords:
Aortic dissectionChemokine and growth factorColony stimulating factorCytokinesInterferonInterleukinTumor necrosis factor

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