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Updated: Feb 6, 2026
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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
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Castration-Resistant Prostate Cancer: AUA Guideline Amendment 2018
William T Lowrance1, Mohammad Hassan Murad1, William K Oh1
1American Urological Association Education and Research, Inc., Linthicum, Maryland.
The Journal of Urology
|August 8, 2018
Summary
This updated guideline incorporates new research to guide the management of non-metastatic castration-resistant prostate cancer (CRPC). It emphasizes shared decision-making for optimal patient treatment strategies.
Area of Science:
- Oncology
- Urology
- Clinical Guidelines
Background:
- Previous guidelines for non-metastatic castration-resistant prostate cancer (CRPC) were based on literature up to 2013 and expert opinion.
- The guideline was previously amended in 2014 and 2015.
- The field of CRPC management is rapidly evolving.
Purpose of the Study:
- To update clinical practice guidelines for non-metastatic castration-resistant prostate cancer (CRPC).
- To incorporate newly published literature into management strategies.
- To provide a rational basis for treating patients with non-metastatic CRPC.
Main Methods:
- A systematic literature search was conducted in 2018, yielding 770 references.
- 47 studies provided relevant data for the amendment.
- Guideline statements were amended based on index patients representing common clinical scenarios.
Main Results:
- The amendment incorporates new information on the treatment of non-metastatic CRPC.
- Updated supporting text and new guideline statements for asymptomatic non-metastatic CRPC were developed.
- Guideline statements were refined based on recent evidence.
Conclusions:
- Guidelines should be used with recent systematic reviews and patient-specific goals.
- Shared decision-making is crucial for selecting management strategies.
- The guideline will be continuously updated with emerging literature.
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