Related Experiment Video
Updated: Aug 17, 2026

10:02
Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs
Published on: July 23, 2016
Diffuse cutaneous hypersensitivity reaction after dexamethasone/polymyxin B/neomycin combination eyedrops
Abstract:
Localized cutaneous hypersensitivity reactions to antibiotic eyedrops are not unusual. To our knowledge, however, a diffuse cutaneous reaction to eyedrops containing dexamethasone/polymyxin B/neomycin has never been reported. We describe the diffuse skin changes noted in a 72-year-old patient five days after starting eyedrop therapy.
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Allergic Reactions
Overview
Ophthalmic Drug Delivery Systems
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

