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1985 Armstrong lecture. Cardiovascular receptors and fluid volume control
Aviation, Space, and Environmental Medicine
|March 1, 1986
Summary
Cardiac receptors play a key role in fluid volume control, influencing hormones like ADH and renin. Heart transplant patients offer new opportunities to study these cardiovascular mechanisms.
Area of Science:
- Cardiovascular Physiology
- Neuroendocrinology
Background:
- Left atrial receptors influence antidiuretic hormone (ADH) release, establishing a cardiovascular basis for fluid volume control.
- Neural mechanisms involving cardiac receptors controlling renin release provide further evidence for their role in fluid balance.
Purpose of the Study:
- To explore the role of cardiac receptors in cardiovascular function.
- To leverage heart transplant patients for advanced research on cardiac receptor function.
Main Methods:
- Utilized negative pressure breathing experiments to identify left atrial receptors.
- Confirmed original experimental findings in canine models.
- Leveraged clinical data from heart transplant recipients.
Main Results:
- Discovery of left atrial receptors impacting ADH release.
- Established the concept of cardiovascular fluid volume control.
- Confirmed the role of cardiac receptors in renin release and fluid homeostasis.
Conclusions:
- Cardiac receptors are integral to the neural control of fluid volume.
- Heart transplant research offers a unique model for further investigation into cardiac receptor function and cardiovascular regulation.