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Related Concept Videos

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Compact Bone

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Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
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Compacting Factor test01:22

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The compacting factor test is a method used to assess the workability of concrete. It is  especially suitable for concrete mixes containing aggregates up to one and a half inches in size. This test involves specialized equipment consisting of two truncated cone-shaped hoppers and a cylinder, all with polished interior surfaces to minimize friction.
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Uncertainty in Measurement: Accuracy and Precision03:37

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Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value. 
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Accuracy and Precision01:52

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Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value.  Highly accurate...
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The Precise Definition of a Limit01:27

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Understanding the formal definition of a limit is essential for precise mathematical analysis. This concept allows us to rigorously determine how a function behaves near a particular point without relying on ambiguous notions such as "getting close." The ε-δ definition plays a foundational role in calculus, ensuring analytical clarity and logical consistency in limit evaluation.The formal definition states that the limit of a function f(x) as x approaches a is L, written asif for...
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In most substances, the current flow is proportional to the voltage applied to it. A simple relationship between the values of current, voltage, and resistance is known as Ohm's law. Nonohmic devices do not exhibit a linear relationship between voltage and current. One such device is the semiconducting circuit element known as a diode. A diode is a circuit device that allows current flow in only one direction.
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Q3: A Compact Device for Quick, High Precision qPCR.

Marco Cereda1, Alessandro Cocci2, Davide Cucchi3

  • 1STMicroelectronics S.r.l., I-20864 Agrate Brianza, Monza Brianza, Italy. marco.cereda@st.com.

Sensors (Basel, Switzerland)
|August 9, 2018
PubMed
Summary
This summary is machine-generated.

A new Q3 system enables accurate on-chip quantitative real-time Polymerase Chain Reaction (qPCR) using disposable Lab-on-a-Chips. This system matches commercial performance for broad qPCR applications.

Keywords:
Lab-on-a-ChipQ3low-cost devicesminiaturizationon-chip diagnosispoint-of-care testsqPCRreal-time PCR

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Area of Science:

  • Biotechnology
  • Analytical Chemistry
  • Microfluidics

Background:

  • Quantitative real-time Polymerase Chain Reaction (qPCR) is a vital molecular biology technique.
  • Existing qPCR systems can be bulky, expensive, and require significant sample volumes.
  • There is a need for miniaturized, user-friendly, and cost-effective qPCR solutions.

Purpose of the Study:

  • To demonstrate and detail an accurate and easy-to-use Q3 system for on-chip quantitative real-time Polymerase Chain Reaction (qPCR).
  • To present the engineering aspects of the Q3 system, including its disposable chip and non-disposable components.
  • To benchmark the performance of the Q3 system against standard commercial qPCR platforms.

Main Methods:

  • Utilized single-use Lab-on-a-Chips with 5-15 µL well capacity for qPCR reactions.
  • Integrated a printed metal heater and calibrated sensor on the chip for precise temperature control.
  • Developed a non-disposable unit with a four-channel fluorescence readout, control system, and data storage, interfaced with user-friendly software.

Main Results:

  • The Q3 system successfully performed on-chip qPCR reactions with high accuracy and ease of use.
  • Engineering details of the integrated system, including thermal control and fluorescence detection, were elucidated.
  • Benchmarking demonstrated that the Q3 system's performance is equivalent to standard commercial qPCR systems.

Conclusions:

  • The Q3 system represents a mature and general-purpose solution for on-chip qPCR.
  • The developed system offers a miniaturized, accurate, and user-friendly alternative to conventional qPCR platforms.
  • This technology has the potential to advance molecular diagnostics and research through accessible on-chip qPCR.