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Rebuilding the Gut Microbiota Ecosystem.

Antonella Gagliardi1, Valentina Totino2, Fatima Cacciotti3

  • 1Department of Public Health and Infectious Diseases, Section of Microbiology, Sapienza University of Rome, Rome 00185, Italy. antonella.gagliardi@uniroma1.it.

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Gut microbiota dysbiosis, an imbalance in the gut microbial ecosystem, is linked to numerous intestinal and extra-intestinal diseases. This review explores various therapeutic strategies to restore gut health and counteract dysbiosis.

Keywords:
dysbiosiseubiosisgut microbiotatherapeutic strategy

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Area of Science:

  • Microbiology
  • Gastroenterology
  • Immunology

Background:

  • Gut microbiota dysbiosis describes an imbalanced microbial ecosystem, disrupting the mutualistic association of bacteria.
  • This condition is implicated in the pathogenesis of both intestinal diseases (e.g., IBS, IBD) and extra-intestinal conditions (e.g., obesity, metabolic disorders, cardiovascular disease, allergies).

Purpose of the Study:

  • To review and discuss diverse therapeutic strategies for counteracting intestinal dysbiosis.
  • To highlight the importance of restoring the balance of the intestinal ecosystem for overall health.

Main Methods:

  • This review synthesizes information on various interventions targeting gut dysbiosis.
  • Strategies discussed include probiotics, prebiotics, synbiotics, phage therapy, fecal microbiota transplantation, bacterial consortium transplantation, and predatory bacteria approaches.

Main Results:

  • Dysbiosis is associated with a wide range of significant pathologies.
  • Multiple therapeutic avenues exist for managing dysbiosis, with varying degrees of investigation.

Conclusions:

  • Restoring gut microbial balance is crucial for managing numerous diseases.
  • A range of therapeutic strategies, from established to novel, are being explored to combat intestinal dysbiosis.