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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Ecological succession is influenced by the processes of facilitation, inhibition, and toleration. Facilitation occurs when early successional species create more favorable ecological conditions for subsequent species, such as enhanced nutrient, water, or light availability. In contrast, inhibition happens when early successional species create unfavorable ecological conditions for potential successive species, such as limiting resource availability. In some cases, later successional species...
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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Kidney Transplant III: Nursing Management

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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
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Robot-Assisted Kidney Transplantation
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Successful kidney transplantation normalizes platelet function.

Claire Kennedy1,2, Limy Wong1, Donal J Sexton1

  • 1Department of Nephrology, Beaumont Hospital, Dublin, Ireland.

Clinical Kidney Journal
|August 9, 2018
PubMed
Summary
This summary is machine-generated.

Kidney transplant recipients with immediate graft function showed restored platelet function. Delayed graft function (DGF) in kidney transplant patients was associated with persistent platelet dysfunction, impacting clinical outcomes.

Keywords:
chronic kidney diseasedelayed graft functionhaemostasisplateletstransplant

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Area of Science:

  • Nephrology
  • Hematology
  • Transplantation immunology

Background:

  • Uremic platelet dysfunction is poorly understood, partly due to non-physiological assays.
  • A novel physiological flow-based assay quantifies platelet function under arterial shear using small blood volumes.
  • This study aimed to characterize platelet function before and after kidney transplantation.

Purpose of the Study:

  • To assess dynamic platelet function in kidney transplant recipients.
  • To compare pre-transplant and post-transplant platelet behavior.
  • To investigate the impact of graft function on platelet recovery.

Main Methods:

  • Employed a physiological flow-based assay to measure platelet function.
  • Analyzed 10 kidney transplant patients and 9 healthy controls.
  • Tracked platelet-von Willebrand factor interactions using specialized software.

Main Results:

  • Pre-transplant patients exhibited significantly reduced platelet-VWF interactions compared to controls.
  • Platelet function normalized in 7/10 patients with immediate graft function.
  • Platelet function remained abnormal in 3/10 patients with delayed graft function (DGF).

Conclusions:

  • Dynamic platelet function normalized post-transplant in patients with immediate graft function.
  • Delayed graft function (DGF) was associated with persistent platelet dysfunction.
  • These findings have clinical implications for managing patients with DGF, who often require invasive procedures.