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Related Concept Videos

Encoding01:19

Encoding

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Information enters the brain through encoding, which is the input of information into the memory system. Once sensory information is received from the environment, the brain labels or codes it. The information is then organized with similar information and connected to existing concepts. Encoding occurs through automatic processing and effortful processing.
Automatic processing involves the encoding of details like time, space, frequency, and the meaning of words, usually done without conscious...
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DNA Microarrays02:34

DNA Microarrays

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Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
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Properties of Enantiomers and Optical Activity02:24

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It is essential to understand the difference between chiral and achiral interactions and the implications thereof in optical activity and their applications. Just as our feet, which are chiral, interact uniquely with chiral objects, such as a pair of shoes, but identically with achiral socks, enantiomers of a molecule exhibit different properties only when they interact with other chiral media. An example of a significant implication from this facet is the phenomenon known as optical activity,...
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Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

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Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
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Lewis Acids and Bases02:33

Lewis Acids and Bases

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In 1923, G. N. Lewis proposed a generalized definition of acid-base behavior in which acids and bases are identified by their ability to accept or to donate a pair of electrons and form a coordinate covalent bond.
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Weak Base Solutions03:21

Weak Base Solutions

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Some compounds produce hydroxide ions when dissolved by chemically reacting with water molecules. In all cases, these compounds react only partially and so are classified as weak bases. These types of compounds are also abundant in nature and important commodities in various technologies. For example, global production of the weak base ammonia is typically well over 100 metric tons annually, being widely used as an agricultural fertilizer, a raw material for chemical synthesis of other...
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Multiplexed Fluorescent Microarray for Human Salivary Protein Analysis Using Polymer Microspheres and Fiber-optic Bundles
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Multiplexed microarrays based on optically encoded microbeads.

Atieh Vafajoo1, Azin Rostami1, Sanam Foroutan Parsa1

  • 1Biomaterials Group, Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.

Biomedical Microdevices
|August 9, 2018
PubMed
Summary
This summary is machine-generated.

Optically encoded microbeads offer a promising platform for early disease biomarker detection. This technology enables accurate, non-invasive diagnostics, potentially improving outcomes for serious illnesses like cancer.

Keywords:
Early diagnosisMicrobeadsMultiplexing technologiesOptical encoding

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Area of Science:

  • Biotechnology
  • Nanotechnology
  • Medical Diagnostics

Background:

  • Growing interest in optically-encoded functionalized microbeads as solid supports for capturing disease biomarkers.
  • Multiplexing technologies using optically encoded microspheres enable detection of subtle biomarker changes.
  • Early detection of biomarkers can facilitate timely diagnosis and treatment of serious diseases, including cancer.

Purpose of the Study:

  • To review the current state-of-the-art in diagnostic microbeads.
  • To summarize microsphere composition, synthesis, encoding, detection systems, and applications.
  • To highlight the potential of microbead-based assays for non-invasive and accurate disease biomarker detection.

Main Methods:

  • Review of existing literature on optically-encoded microbeads.
  • Analysis of microsphere properties, including composition and synthesis.
  • Examination of encoding technologies and detection systems for microbead assays.

Main Results:

  • Optically encoded microbeads serve as a versatile platform for biomarker capture.
  • Multiplexed assays enhance the ability to detect minor biomarker alterations.
  • Current diagnostic methods often lack accuracy, highlighting the need for advanced techniques.

Conclusions:

  • Optically encoded microbeads represent an emerging technology for disease diagnostics.
  • Further research is needed to advance detection systems and applications.
  • These microbeads hold significant potential for non-invasive, accurate biomarker detection and early disease diagnosis.