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Updated: Feb 6, 2026
miRNA Expression Analyses in Prostate Cancer Clinical Tissues
Published on: September 8, 2015
[Expressions of Bcl-xl and caspase-3 in the prostate cancer tissue and their correlation]
Objective:
To investigate the expressions of Bcl-xl and caspase-3 in the tissues of benign prostatic hyperplasia(BPH) and prostate cancer(PCa) and their correlation.
Methods:
Using immunohistochemical methods, we determined the expressions of Bcl-xl and caspase-3 in 20 cases of BPH and 35 cases of PCa and analyzed their correlation.
Results:
The positive rates of Bcl-xl in the BPH and PCa tissues were 45. 00% and 88. 57%,and those of caspase-3 were 60. 00% and 17. 14%,respectively. The expressions of Bcl-xl and caspase-3 in the PCa tissue were not correlated with the preoperative PSA level, the risk of distant metastasis, Gleason scores, and clinical stages( P > 0. 05),and there was a negative correlation between the expressions of the two proteins in PCa( rs=- 0. 748,P < 0. 05).
Conclusion:
The expression of Bcl-xl was upregulated while that of caspase-3 downregulated significantly in the PCa tissue, which indicates a possible interaction between the two proteins in cell apoptosis.
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