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Esophageal Varices-I: Introduction

Esophageal Varices-I: Introduction

Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...

What is Genetic Engineering?

What is Genetic Engineering?

Esophageal Perforation-I: Introduction

Esophageal Perforation-I: Introduction

Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus....

Esophageal Strictures-I: Introduction

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...

Esophageal Strictures-II: Clinical Features and Management

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...

Esophageal Perforation-II: Clinical Manifestations and Management

Esophageal Perforation-II: Clinical Manifestations and Management

Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:

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Related Experiment Video

Updated: Feb 6, 2026

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats

Published on: February 10, 2020

Esophageal tissue engineering: from bench to bedside.

Lousineh Arakelian^1,2, Nobuo Kanai^3,4, Kulwinder Dua⁵

¹Cell Therapy Unit, AP-HP, Saint-Louis Hospital, Paris Diderot University, Paris, France.

Annals of the New York Academy of Sciences

|August 9, 2018

Summary

This summary is machine-generated.

Tissue engineering offers new esophageal repair methods using cell sheets or scaffolds. These innovative tissue-engineered substitutes aim to remodel esophageal tissue and prevent strictures after surgery.

Keywords:

cell sheet technology clinical trials decellularized scaffold esophagus regenerative medicine tissue engineering

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Last Updated: Feb 6, 2026

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats

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Published on: February 10, 2020

Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model

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Published on: May 18, 2015

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation

Published on: March 22, 2017

Area of Science:

Regenerative Medicine
Gastroenterology
Biomaterials Science

Background:

Esophageal diseases necessitate advanced tissue repair solutions.
Tissue engineering provides in vitro methods for in vivo esophageal regeneration.
Current research focuses on cell-based and scaffold-based esophageal substitutes.

Purpose of the Study:

To review recent advancements in esophageal tissue engineering.
To discuss cell sheet technology for preventing esophageal strictures.
To explore full-thickness esophageal replacement using engineered substitutes.

Main Methods:

Review of current literature on esophageal tissue engineering.
Analysis of cell sheet technology applications.
Evaluation of tissue-engineered substitutes for esophageal replacement.

Main Results:

Cell sheet technology shows promise in preventing strictures post-esophagectomy.
Tissue-engineered substitutes are being developed for full-thickness esophageal replacement.
Combinations of cells and scaffolds offer tailored solutions based on lesion severity.

Conclusions:

Tissue engineering represents a significant advancement in treating esophageal diseases.
Cell sheet technology and engineered substitutes hold potential for esophageal repair and reconstruction.
Further research is crucial for clinical translation of these regenerative approaches.