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Menthol ameliorates voiding dysfunction in types I and II diabetic mouse model.

Mariana G de Oliveira1, Daniel M Nascimento1, Eduardo C Alexandre1

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Menthol effectively reduced overactive bladder symptoms in mouse models of type 1 and type 2 diabetes. This study suggests menthol as a potential treatment for diabetic bladder complications.

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Area of Science:

  • Urology
  • Pharmacology
  • Diabetology

Background:

  • Overactive bladder (OAB) is a common complication in both type 1 (T1DM) and type 2 diabetes mellitus (T2DM).
  • Menthol is known to reduce the micturition reflex threshold in healthy bladders, but its effects in diabetic conditions were previously unevaluated.
  • Diabetic OAB presents with altered bladder capacity, contractility, and voiding patterns.

Purpose of the Study:

  • To investigate the therapeutic potential of menthol in ameliorating OAB symptoms in mouse models of T1DM and T2DM.
  • To assess the effects of menthol on cystometric alterations and in vitro bladder contractility in diabetic conditions.

Main Methods:

  • Type 1 diabetes mellitus (T1DM) was induced using streptozotocin (STZ) and type 2 diabetes mellitus (T2DM) via a high-fat diet (HFD) in mice.
  • Urodynamic profiles were evaluated using filling cystometry with intravesical menthol infusion.
  • In vitro bladder contractility was measured in response to carbachol, KCl, and electrical-field stimulation (EFS) after menthol incubation.

Main Results:

  • Menthol infusion significantly reduced elevated bladder capacity, threshold pressure, and non-voiding contractions (NVCs) in STZ-induced T1DM mice.
  • In HFD-induced T2DM mice, menthol attenuated increased threshold pressure and NVC frequency.
  • Menthol incubation normalized enhanced bladder contractile responses to various stimuli in both diabetic models.

Conclusions:

  • Menthol demonstrates significant efficacy in mitigating key OAB parameters in experimental models of T1DM and T2DM.
  • These findings support menthol as a promising pharmacological candidate for managing diabetic-associated overactive bladder.
  • Further research is warranted to explore menthol's clinical application in treating OAB in diabetic patients.