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Related Concept Videos

Accelerators01:17

Accelerators

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Accelerators in concrete serve as admixtures to speed up the hardening process, enabling the concrete to achieve early strength faster. Although accelerators do not necessarily impact the time it takes concrete to set, they reduce this time in practice. A common accelerator is calcium chloride, which is particularly useful for hastening early strength development in cold weather or for rapid repair jobs that require quick heat generation after mixing.
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Abnormal Proliferation02:23

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Average Acceleration01:30

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The importance of understanding acceleration spans our day-to-day experiences, as well as the vast reaches of outer space and the tiny world of subatomic physics. In everyday conversation, to accelerate means to speed up. For instance, we are familiar with the acceleration of our car; the harder we apply our foot to the gas pedal, the faster we accelerate. The greater the acceleration, the greater the change in velocity over a given time. Acceleration is widely seen in experimental physics. In...
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Acceleration is in the direction of the change in velocity, but it is not always in the direction of motion. When an object slows down, its acceleration is opposite to the direction of its motion. Although commonly referred to as deceleration, this causes confusion in our analysis as deceleration is not a vector, and does not point to a specific direction with respect to a coordinate system. Therefore, the term deceleration is not used. For example, when a subway train slows down, it...
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In everyday conversation, accelerating means speeding up. Acceleration is a vector in the same direction as the change in velocity, Δv, therefore the greater the acceleration, the greater the change in velocity over a given time. Since velocity is a vector, it can change in magnitude, direction, or both. Thus acceleration is a change in speed or direction, or both. For example, if a runner traveling at 10 km/h due east slows to a stop, reverses direction, and continues their run at 10 km/h...
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Accelerating Fluids01:17

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When a fluid is in constant acceleration, the pressure and buoyant force equations are modified. Suppose a beaker is placed in an elevator accelerating upward with a constant acceleration, a. In the beaker, assume there is a thin cylinder of height h with an infinitesimal cross-sectional area, ΔS.
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Accelerated Epithelial Proliferation in a Rabbit Model of Bullous Keratopathy.

Kazunari Higa, Yuichi Uchino, Motoko Kawashima

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    Bullous keratopathy (BK) may accelerate corneal epithelial cell proliferation. This study investigated BK

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    Area of Science:

    • Ophthalmology
    • Corneal Disease Research
    • Cell Biology

    Background:

    • Long-standing bullous keratopathy (BK) is linked to peripheral conjunctivalization and limbal deficiency.
    • Limbal deficiency may result from accelerated corneal epithelial cell proliferation.

    Purpose of the Study:

    • To investigate the influence of bullous keratopathy (BK) on corneal epithelial cell proliferation.
    • To test the hypothesis that limbal deficiency in BK is induced by accelerated corneal epithelial cell proliferation.

    Main Methods:

    • Induction of bullous keratopathy (BK) in rabbits via continuous curvilinear descemetorhexis.
    • Histochemical analysis using BrdU pulse chase methods to evaluate corneal epithelial cell proliferation.
    • Assessment of Ki67 positive cells and telomere intensity in corneal epithelium.

    Main Results:

    • Rabbit corneas exhibited stromal edema and increased thickness post-surgery.
    • Peripheral corneal vascularization was observed, but conjunctivalization was rare at 6 weeks.
    • A trend towards lower BrdU positive cells but increased Ki67 positive cells was noted in BK corneal epithelium.

    Conclusions:

    • Bullous keratopathy (BK) may accelerate corneal epithelial cell proliferation in a rabbit model.
    • Further research is needed to fully elucidate the mechanisms linking BK, limbal deficiency, and epithelial cell dynamics.