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De Novo Generation of Somatic Stem Cells by YAP/TAZ

De Novo Generation of Somatic Stem Cells by YAP/TAZ

Published on: May 7, 2018

Interplay between YAP/TAZ and Metabolism.

Ja Hyun Koo¹, Kun-Liang Guan¹

¹Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.

Cell Metabolism

|August 9, 2018

Summary

This summary is machine-generated.

Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) integrate metabolic signals to regulate cell growth and tissue homeostasis. These coactivators are inhibited by low energy levels but promote metabolic pathways like glycolysis when active.

Keywords:

AMPK GPCR Hippo TAZ TEAD YAP cancer metabolism

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Area of Science:

Cell Biology
Metabolism
Molecular Biology

Background:

Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are homologous transcriptional coactivators crucial for cell proliferation, stem cell maintenance, and tissue homeostasis.
These coactivators are active under favorable conditions, promoting cell growth via TEAD transcription factors, and are inhibited by low cellular energy levels.

Purpose of the Study:

To review the recent findings on the interplay between YAP/TAZ and cellular metabolism.
To highlight the role of YAP and TAZ as integrators of metabolic cues that coordinate nutrient availability with cell growth and tissue homeostasis.

Main Methods:

Literature review of recent studies on YAP/TAZ and metabolism.
Analysis of the regulatory roles of metabolic factors on YAP/TAZ activity.
Examination of the impact of YAP/TAZ on metabolic pathways.

Main Results:

Metabolic factors such as glucose, fatty acids, and hormones directly regulate YAP and TAZ activity.
YAP and TAZ promote key metabolic pathways including glycolysis, lipogenesis, and glutaminolysis.
YAP and TAZ act as central nodes connecting nutrient availability to cellular growth and tissue maintenance.

Conclusions:

YAP and TAZ are critical regulators that integrate metabolic status with cellular growth.
Understanding the YAP/TAZ-metabolism axis is essential for comprehending tissue homeostasis and disease.
This review provides a comprehensive overview of YAP and TAZ as key players in metabolic regulation.