Related Experiment Video
Updated: Feb 6, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
Efficacy and tolerability of a house dust mite allergoid in allergic bronchial asthma: a randomized dose-ranging
Marek Jutel1,2, Michael Rudert3, Fabian Kreimendahl3
1"ALL-MED" Medical Research Institute, Wroclaw, Poland.
Aim:
This multicenter randomized placebo-controlled double-blind clinical trial investigated which maintenance dose shows the optimal benefit-risk ratio for subcutaneous immunotherapy with a Dermatophagoides pteronyssinus allergoid preparation.
Objective:
To evaluate four maintenance doses of the allergoid preparation versus placebo.
Methods:
The late-phase reaction of the intracutaneous test was chosen as efficacy parameter and minimal dose of fluticasone required for asthma control.
Results:
A total of 146 adults with bronchial asthma were randomized. After subcutaneous immunotherapy, reductions in swelling size were greatest with 10,000 therapeutic units (TU). The 18,000 TU group showed the highest percentage of patients with fluticasone dose reduced to 0 μg/day.
Conclusion:
The optimal dose of allergoid for the investigation in a confirmatory trial with inhaled corticosteroid reduction is 18,000 TU.
Related Concept Videos
Allergic Reactions
Dose-Response Relationship: Potency and Efficacy
The Bronchial Tree
The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...
Range
15.9; 16.1; 15.2; 14.8; 15.8; 15.9; 16.0; 15.5
Measurements of the amount of soda in a 16-ounce can vary since different subjects record these measurements or since the exact amount - 16 ounces of liquid, was not...
Asthma-I: Introduction
Allergic Drug Reactions

