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Updated: Feb 6, 2026

Optical Recording of Suprathreshold Neural Activity with Single-cell and Single-spike Resolution
Published on: September 5, 2012
Persistent Spiking Activity Underlies Working Memory
Christos Constantinidis1, Shintaro Funahashi2,3, Daeyeol Lee4,5,6,7
1Department of Neurobiology & Anatomy, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, cconstan@wakehealth.edu.
Abstract:
Persistent activity generated in the PFC during the delay period of working memory tasks represents information about stimuli held in memory and determines working memory performance. Alternative models of working memory, depending on the rhythmicity of discharges or exclusively on short-term synaptic plasticity, are inconsistent with the neurophysiological data.Dual Perspectives Companion Paper:Working Memory: Delay Activity, Yes! Persistent Activity? Maybe Not, by Mikael Lundqvist, Pawel Herman, and Earl K. Miller.
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