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Studying cancer immunotherapy using patient-derived xenografts (PDXs) in humanized mice

Yunsik Choi1, Sanghyuk Lee1, Kapyoul Kim1

  • 1Department of Life Sciences, Ewha Womans University, Seoul, Korea.

Experimental & Molecular Medicine
|August 10, 2018
PubMed

Cancer immunotherapy is a promising way to eliminate tumor cells by using the patient's own immune system. Selecting the appropriate animal models to develop or validate preclinical immunotherapeutic trials is now an important aspect of many cancer research programs. Here we discuss the advantages and limitations of using genetically engineered immunodeficient mouse models, patient-derived xenografts (PDXs), and humanized mouse models for developing and testing immunotherapeutic strategies.

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