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Related Experiment Video

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Imaging the Human Immunological Synapse
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Immunological changes in depression.

Sunil Goyal1, Kalpana Srivastava2, Chaitanya Kodange1

  • 1Department of Psychiatry, INHS Asvini, Mumbai, Maharashtra, India.

Industrial Psychiatry Journal
|August 10, 2018
PubMed
Summary

Depression is linked to immune system dysregulation, with altered cellular and humoral immunity markers. Antidepressant treatment in patients with depression significantly impacts these immune markers.

Keywords:
Antidepressant treatmentdepressionimmunological response

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Area of Science:

  • Immunology
  • Psychiatry
  • Neuroscience

Background:

  • Investigates the under-researched role of the immune system in depression pathophysiology within the Indian context.
  • Highlights the sparse existing Indian literature on immune responses in depressive disorders.

Purpose of the Study:

  • To assess the immunological response in patients diagnosed with depressive disorders.
  • To evaluate changes in immune markers before and after antidepressant treatment.

Main Methods:

  • A study involving 100 subjects: 50 with depression (ICD-10 criteria) and 50 healthy controls.
  • Assessed cellular immunity (NK cells, CD4, CD8) and humoral immunity (IL-2, IL-6, CRP) in both groups.
  • Reassessed immune markers in depressed patients after 8 weeks of antidepressant treatment (SSRIs or TCAs).

Main Results:

  • Depressed patients showed significantly higher NK cells, while controls had higher CD4 and CD8 cells (P=0.001).
  • Post-treatment, cell-mediated immunity markers (NK, CD4, CD8) increased significantly (P<0.001).
  • Humoral immunity markers (CRP, IL-2) decreased significantly, while IL-6 levels increased significantly (P<0.001) after treatment.

Conclusions:

  • Depression is associated with immune response dysregulation, affecting both cell-mediated and humoral immunity.
  • Antidepressant therapy demonstrably alters the immune status in patients experiencing depression.