Helicobacter pylori and extragastric diseases: A review

Area of Science:

• Gastroenterology and Infectious Diseases
• Systemic Manifestations of Infection

Background:

• Helicobacter pylori (H. pylori) infection is highly prevalent, affecting roughly half the global population.
• While known for causing gastric diseases, H. pylori has been linked to extragastric manifestations since 1994.

Purpose of the Study:

• To review and discuss reported extragastric manifestations of H. pylori infection.
• To highlight diseases beyond the gastrointestinal tract associated with H. pylori.

Main Methods:

• Literature review of studies reporting H. pylori-associated extragastric diseases.
• Focus on neurological, dermatological, hematologic, ocular, cardiovascular, metabolic, allergic, and hepatobiliary conditions.

Main Results:

• H. pylori infection is associated with a wide range of systemic diseases.
• Manifestations include neurological, dermatological, hematologic, ocular, cardiovascular, metabolic, allergic, and hepatobiliary conditions.

Conclusions:

• H. pylori infection extends beyond the stomach, impacting multiple organ systems.
• Understanding these extragastric effects is crucial for comprehensive patient management.